Research Assistant Professor, Neurobiology
PhD – Kyushu University (2011)
MD – Nagoya University (2002)
Office: W1453 BSTWR
203 Lothrop Street,
Pittsburgh, PA 15213-2548
Neural Circuit for Itch and Pain:
The somatosensory system is a complex system that responds to changes to the surface or internal state of the body, giving rise to the perceptions of touch, pain, itch and temperature. Stimuli are initially detected at the organs such as skin, and this information is transmitted to the spinal cord. Spinal microcircuits modulate and integrate those signals and this information is transmitted to the brain via spinal projection neurons. However, the neural circuits through which spinal cord neurons encode and discriminate pain, itch, touch and temperature are almost completely unknown. Itch, in particular, is an aversive sensation that can ruin a patient’s quality of life, and for which there are no good treatments. Therefore, the long-term goal of my research is to address how somatosensory inputs are integrated and processed in the spinal cord, with a particular focus on itch.
To tackle the question how spinal microcircuits modulate somatosensory input, I developed a novel electrophysiological technique which allows us, for the first time, to record neural activity of a specific population of spinal cord neurons that are labeled with fluorescent marker while we are applying natural stimulation onto the skin (Hachisuka et al., 2016). Thus, I am now poised to address questions about spinal circuitry that were previously elusive.
Using this new method, I am trying answer following questions: (1) how itch and pain are encoded in the spinal projection neurons; (2) how itch and pain signal are modulated by the spinal interneurons.
Hachisuka J, Baumbauer KM, Omori Y, Snyder LM, Koerber HR, Ross SE.
Elife. 2016 Dec 19;5. pii: e22866.
Chiang MC, Hachisuka J, Todd AJ, Ross SE.
Pain. 2016 Mar;157(3):544-5.
Baumbauer KM, DeBerry JJ, Adelman PC, Miller RH, Hachisuka J, Lee KH, Ross SE, Koerber HR, Davis BM, Albers KM.
Elife. 2015 Sep 2;4.
Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M.
Nat Med. 2015 Aug;21(8):927-31.
Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes.
Nakahara T, Mitoma C, Hashimoto-Hachiya A, Takahara M, Tsuji G, Uchi H, Yan X, Hachisuka J, Chiba T, Esaki H, Kido-Nakahara M, Furue M.
J Med Food. 2015 Oct;18(10):1143-9.
Hachisuka J, Ross SE.
Neurosci Lett. 2014 Sep 5;579:188-9.
Ross SE, Hachisuka J, Todd AJ.
Kardon AP, Polgár E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE.
Neuron. 2014 May 7;82(3):573-86.
Aberrant expression of S100A6 and matrix metalloproteinase 9, but not S100A2, S100A4, and S100A7, is associated with epidermal carcinogenesis.
Zhu L, Kohda F, Nakahara T, Chiba T, Tsuji G, Hachisuka J, Ito T, Tu Y, Moroi Y, Uchi H, Furue M.
J Dermatol Sci. 2013 Dec;72(3):311-9.
Verruciform xanthoma of the glans penis mimicking squamous cell carcinoma – role of scavenger receptor positive macrophages.
Miake S, Nakahara T, Kurihara Y, Hachisuka J, Moroi Y, Furue M.
Eur J Dermatol. 2012 May-Jun;22(3):391-2.
Kudo K, Nakahara T, Hachisuka J, Masuda T, Miake S, Moroi Y, Kiryu H, Furue M.
Eur J Dermatol. 2012 Mar-Apr;22(2):256-7.
Combination cryosurgery with hyperthermia in the management of skin metastasis from breast cancer: A case report.
Hachisuka J, Doi K, Furue M.
Int J Surg Case Rep. 2012;3(2):68-9.
Successful treatment of epidermal growth factor receptor inhibitor-induced periungual inflammation with adapalene.
Hachisuka J, Doi K, Moroi Y, Furue M.
Case Rep Dermatol. 2011 May;3(2):130-6.
Hachisuka J, Yunotani S, Shidahara S, Moroi Y, Furue M.
J Am Acad Dermatol. 2011 Feb;64(2):e20-1.
Are lifetime prevalence of impetigo, molluscum and herpes infection really increased in children having atopic dermatitis?
Hayashida S, Furusho N, Uchi H, Miyazaki S, Eiraku K, Gondo C, Tsuji G, Hachisuka J, Fukagawa S, Kido M, Nakahara T, Moroi Y, Hayashi J, Hagihara A, Furue M.
J Dermatol Sci. 2010 Dec;60(3):173-8.
Responsiveness of C neurons in rat dorsal root ganglion to 5-hydroxytryptamine-induced pruritic stimuli in vivo.
Hachisuka J, Furue H, Furue M, Yoshimura M.
J Neurophysiol. 2010 Jul;104(1):271-9.
Severity of disease, rather than xerosis, correlates with pruritus in patients with atopic dermatitis.
Hachisuka J, Takeuchi S, Kido M, Fukiwake N, Furue M.
Int J Dermatol. 2009 Apr;48(4):374-8.
Hachisuka J, Soga-Sakakibara S, Kubota M, Narita K, Kuba K.
Neuroscience. 2007 Apr 25;146(1):123-34.
Hachisuka J, Ichikawa M, Moroi Y, Urabe K, Furue M.
Int J Dermatol. 2006 Dec;45(12):1406-7.
Functional coupling of Ca(2+) channels to ryanodine receptors at presynaptic terminals. Amplification of exocytosis and plasticity.
Narita K, Akita T, Hachisuka J, Huang S, Ochi K, Kuba K.
J Gen Physiol. 2000 Apr;115(4):519-32.