Pain Journal Club

Stay current with advances in the field of pain research!              The Pain Journal Club meets weekly during the fall and spring semesters to discuss cutting edge papers about pain, from mechanisms to circuitry. Presentations are made by Pain Center trainees (graduate student and postdocs) but the emphasis is on interactive discussions. All are welcome to attend. Students are welcome to take this as a one-credit class (MSNBIO 2651). Meetings are Tuesdays at noon in BST 1495. For more information, or if you would like to be able to virtually attend these meetings, contact Brad Taylor (

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Current Journal Club  Schedule Spring 2021

21-Jan   Brian Davis

PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1

Chen G, Kim YH, Li H, Luo H, Liu DL, Zhang ZJ, Lay M, Chang W, Zhang YQ, Ji RR. Nat Neurosci. 2017 Jul;20(7):917-926. doi: 10.1038/nn.4571.

28-Jan   Andrew Liu (Kaplan Lab)

STING controls nociception via type I interferon signalling in sensory neurons

Donnelly CR, Jiang C, Andriessen AS, Wang K, Wang Z, Ding H, Zhao J, Luo X, Lee MS, Lei YL, Maixner W, Ko MC, Ji RR. Nature. 2021 Jan 13. doi: 10.1038/s41586-020-03151-1. Online ahead of print.

4-Feb    Charlie Warwick (Ross/Koerber Lab)

A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior

Tashima R, Koga K, Yoshikawa Y, Sekine M, Watanabe M, Tozaki-Saitoh H, Furue H, Yasaka T, Tsuda M. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2021220118. doi: 10.1073/pnas.2021220118.

11-Feb  David Ferreira (Seal Lab)

Single cell transcriptomics of primate sensory neurons identifies cell types associated with human chronic pain

Kupari, J, Usoskin D, Lou D, Parisien M, Hu Y, Fatt M, Lönnerberg P, Spångberg M, Eriksson B, Barkas N, Kharchenko PV, Loré K, Khoury S, Diatchenko L, and Ernfors P (2021) bioRxiv preprint doi:

18-Feb  Jane Hartung (Gold Lab)

Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans.

Case LK, Liljencrantz J, Madian N, Necaise A, Tubbs J, McCall M, Bradson ML, Szczot M, Pitcher MH, Ghitani N, Frangos E, Cole J, Bharucha-Goebel D, Saade D, Ogata T, Donkervoort S, Foley AR, Bönnemann CG, Olausson H, Bushnell MC, Chesler AT. Nat Commun. 2021 Jan 28;12(1):657. doi: 10.1038/s41467-021-20939-5.

25-Feb  Kayla Nguyen (Taylor Lab)

Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury.

Davoli-Ferreira M, de Lima KA, Fonseca MM, Guimarães RM, Gomes FI, Cavallini MC, Quadros AU, Kusuda R, Cunha FQ, Alves-Filho JC, Cunha TM. Pain. 2020 Aug;161(8):1730-1743. doi: 10.1097/j.pain.0000000000001879. Epub 2020 Mar 26.

4-Mar   Tayler Sheahan (Ross Lab)

A spinal neural circuitry for converting touch to itch sensation

Chen S, Gao XF, Zhou Y, Liu BL, Liu XY, Zhang Y, Barry DM, Liu K, Jiao Y, Bardoni R, Yu W, Chen ZF. Nat Commun. 2020 Oct 8;11(1):5074. doi: 10.1038/s41467-020-18895-7.

11-Mar Cynthia Arokiaraj (Seal Lab)

Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury

Niehaus JK, Taylor-Blake B, Loo L, Simon JM, Zylka MJ. 2021 Neuron 109:1-9.

18-Mar Jeremy Gedeon (Gold Lab)

Keratinocytes Communicate with Sensory Neurons via Synaptic-like Contacts.

Talagas M, Lebonvallet N, Leschiera R, Sinquin G, Elies P, Haftek M, Pennec JP, Ressnikoff D, La Padula V, Le Garrec R, L'herondelle K, Mignen O, Le Pottier L, Kerfant N, Reux A, Marcorelles P, Misery L. Ann Neurol. 2020 Dec;88(6):1205-1219. doi: 10.1002/ana.25912. Epub 2020 Oct 10

25-Mar Sara Trbojevic (Almarza Lab)

Females have greater susceptibility to develop ongoing pain and central sensitization in a rat model of temporomandibular joint pain.

Sannajust S, Imbert I, Eaton V, Henderson T, Liaw L, May M, Barbe MF, King T. Pain. 2019 Sep;160(9):2036-2049. doi: 10.1097/j.pain.0000000000001598.

1-Apr    Meagan Makarcyk (Lin Lab)

Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis.

Zhu J, Zhen G, An S, Wang X, Wan M, Li Y, Chen Z, Guan Y, Dong X, Hu Y, Cao X. Elife. 2020 May 22;9:e57656. doi: 10.7554/eLife.57656.

8-Apr    Kenny Roman

15-Apr  Ruby Holland (Ross Lab)

22-Apr  Sydney Lamerand(Taylor Lab)

Previous Journal Club  Schedules

Fall 2020

Aug 20th - Eileen Nguyen (Ross Lab)

Orchestrating Opiate-Associated Memories in Thalamic Circuits

Keyes PC, Adams EL, Chen Z, Bi L, Nachtrab G, Wang VJ, Tessier-Lavigne M, Zhu Y, Chen X. Neuron 2020 ;S0896-6273(20)30482-7. doi: 10.1016

Sept 1st - David Ferreira (Seal Lab) - Note this is a Tuesday

Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

Raoof R, van der Vlist M, Willemen HDLDM, Prado J, Versteeg S, Vos M, Lokhorst RE, Pasterkamp RJ, Khoury-Hanold, W, Meyaard L, Eijkelkamp N. 2020 bioRxiv doi:

Sept 3rd - Jeremy Gedeon (Gold Lab)

Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception.

Neubarth NL, Emanuel AJ, Liu Y, Springel MW, Handler A, Zhang Q, Lehnert BP, Guo C, Orefice LL, Abdelaziz A, DeLisle MM, Iskols M, Rhyins J, Kim SJ, Cattel SJ, Regehr W, Harvey CD, Drugowitsch J, Ginty DD. Science. 2020 Jun 19;368(6497):eabb2751. doi: 10.1126/science.abb2751.

Sept 10th - Diogo Santos (Taylor Lab)

Neuroendocrine mechanisms governing sex-differences in hyperalgesic priming involve prolactin receptor sensory neuron signaling

Paige C, Barba-Escobedo PA, Mecklenburg J, Patil M, Goffin V, Grattan DR, Dussor G, Akopian AN, Price TJ. J Neurosci. 2020 Aug 12;JN-RM-1499-20. doi: 10.1523/JNEUROSCI.1499-20.2020

Sept 17th - Kim Meerschaert (Davis Lab)

An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents

Prescott SL, Umans BD, Williams EK, Brust RD, Liberles SD. Cell 2020 Apr 30;181(3):574-589.e14. doi: 10.1016/j.cell.2020.03.004. Epub 2020 Apr 6. PMID: 32259485 PMCID: PMC7197391 (available on 2021-04-30) DOI: 10.1016/j.cell.2020.03.004

Sept 24th - Kelly Smith (Ross Lab)

Low-threshold mechanosensitive VGLUT3-lineage sensory neurons mediate spinal inhibition of itch by touch.

Sakai K, Sanders KM, Lin S-H, Pavlenko D, Funahashi H, Lozada T, Hao S, Chen C-C, Akiyama T. J Neurosci. 2020 Sep 7;JN-RM-0091-20. doi: 10.1523/JNEUROSCI.0091-20.2020. Online ahead of print.

Oct  1st - Jamie Moy (Gold Lab)

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, Stratton HJ, Cai S, Luo S, Gonzalez KB, Miller SP, Patwardhan A, Ibrahim MM, Khanna R. bioRxiv preprint doi: this version posted September 14, 2020

Oct 8th - Yanmei Qi (Taylor Lab)

Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids

Zhang X-Y, Dou Y-N, Yuan L, Li Q, Zhu YJ, Wang M, Sun YG. Elife. 2020 Jun 10;9:e55289. doi: 10.7554/eLife.55289.

Oct 15th - Andrew Liu (Kaplan Lab)

Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain

Barragán-Iglesias P, Franco-Enzástiga Ú, Jeevakumar V, Shiers S, Wangzhou A, Granados-Soto V, Campbell ZT, Dussor G, Price TJ. J Neurosci. 2020 Apr 29;40(18):3517-3532. doi: 10.1523/JNEUROSCI.3055-19.2020.

Oct 22nd - Sam Noh (Seal Lab)

Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity

Kohro Y, Matsuda T, Yoshihara K, Kohno K, Koga K, Katsuragi R, Oka T, Tashima R, Muneta S, Yamane T, Okada S, Momokino K, Furusho A, Hamase K, Oti T, Sakamoto H, Hayashida K, Kobayashi R, Horii T, Hatada I, Tozaki-Saitoh H, Mikoshiba K, Taylor V, Inoue K, Tsuda M. Nat Neurosci. 2020 Oct 5. doi: 10.1038/s41593-020-00713-4. Online ahead of print..

Oct 29th - Benjamin Warner (Kinchington Lab)

Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents

Tiwari V, He S-Q, Huang Q, Liang L, Yang F, Chen Z, Tiwari V, Fujita W, Devi LA, Dong X, Guan Y, Raja SN. Pain 2020 Apr;161(4):842-855. doi: 10.1097/j.pain.0000000000001768.

Supplemental Material

Nov 5th - Chris Norris (Taylor Lab)

Histone methyltransferase G9a diminishes expression of cannabinoid CB 1 receptors in primary sensory neurons in neuropathic pain

Luo Y, Zhang J, Chen L, Chen S-R, Chen H, Zhang G, Pan H-L. J Biol Chem. 2020 Mar 13;295(11):3553-3562. doi: 10.1074/jbc.RA119.011053. Epub 2020 Feb 4.

Nov 12th - Ariel Epouhe (Albers Lab)

Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.

Perner C, Flayer CH, Zhu X, Aderhold PA, Dewan ZNA, Voisin T, Camire RB, Chow OA, Chiu IM, Sokol CL. Immunity. 2020 Oct 21:S1074-7613(20)30413-1. doi: 10.1016/j.immuni.2020.10.001. Online ahead of print.

Nov 19th - Joyce Kim (Gold Lab)

Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia.

Dong W, Jin SC, Allocco A, Zeng X, Sheth AH, Panchagnula S, Castonguay A, Lorenzo LÉ, Islam B, Brindle G, Bachand K, Hu J, Sularz A, Gaillard J, Choi J, Dunbar A, Nelson-Williams C, Kiziltug E, Furey CG, Conine S, Duy PQ, Kundishora AJ, Loring E, Li B, Lu Q, Zhou G, Liu W, Li X, Sierant MC, Mane S, Castaldi C, López-Giráldez F, Knight JR, Sekula RF Jr, Simard JM, Eskandar EN, Gottschalk C, Moliterno J, Günel M, Gerrard JL, Dib-Hajj S, Waxman SG, Barker FG 2nd, Alper SL, Chahine M, Haider S, De Koninck Y, Lifton RP, Kahle KT. iScience. 2020 Sep 11;23(10):101552. doi: 10.1016/j.isci.2020.101552. eCollection 2020 Oct 23.

Supplemental tables

Summer 2020 (COVID-19) Schedule

April 30, 2020 - Nicole Scheff

Loss of p53 drives neuron reprogramming in head and neck cancer

Amit M, Takahashi H, Dragomir MP, Lindemann A, Gleber-Netto FO, Pickering CR, Anfossi S, Osman AA, Cai Y, Wang R, Knutsen E, Shimizu M, Ivan C, Rao X, Wang J, Silverman DA, Tam S, Zhao M, Caulin C, Zinger A, Tasciotti E, Dougherty PM, El-Naggar A, Calin GA, Myers JN. Nature. 2020 Feb;578(7795):449-454. doi: 10.1038/s41586-020-1996-3.

May 7, 2020 - Special Seminar: Diego Bohorquez, PhD

“How the Gut Drives our Sugar Preferences”

May 14, 2020 - Paramita Basu (Tayler Lab)

Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels.

Zhou X, Ma T, Yang L, Peng S, Li L, Wang Z, Xiao Z, Zhang Q, Wang L, Huang Y, Chen M, Liang S, Zhang X, Liu JY, Liu Z. Nat Commun. 2020 May 8;11(1):2293. doi: 10.1038/s41467-020-16210-y.

May 21, 2020 - Emanuel Loeza Alcocer (Gold Lab)

Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache.

Bonnet C, Hao J, Osorio N, Donnet A, Penalba V, Ruel J, Delmas P. Nat Commun. 2019 Sep 18;10(1):4253. doi: 10.1038/s41467-019-12197-3.

May 28, 2020 - Tayler Sheahan (Ross Lab)

Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons

Sharif B, Ase AR, Ribeiro-da-Silva A, Séguéla P

Neuron. 2020 Apr 7;S0896-6273(20)30228-2. doi: 10.1016/j.neuron.2020.03.021.


 Spring 2020

January 9th 2020 - Hailey Bulls

Self-Guided Online Cognitive Behavioral Strategies for Chemotherapy-Induced Peripheral Neuropathy: A Multicenter, Pilot, Randomized, Wait-List Controlled Trial

Knoerl R, Smith EML, Barton DL, Williams DA, Holden JE, Krauss JC, LaVasseur B. J Pain. 2018 Apr;19(4):382-394. doi: 10.1016/j.jpain.2017.11.009. Epub 2017 Dec 8.

January 16th, 2020 - G Sinha (Taylor lab)

Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes

Mapplebeck JCS, Lorenzo LE, Lee KY, Gauthier C, Muley MM, De Koninck Y, Prescott SA, Salter MW. Cell Rep. 2019 Jul 16;28(3):590-596.e4. doi: 10.1016/j.celrep.2019.06.059.

January 23rd, 2020 - K Meerschaert (Davis lab)

Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.

Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Cell. 2020 Jan 9;180(1):33-49.e22. doi: 10.1016/j.cell.2019.11.014.

January 30th, 2020 - S Puig (Mahajan lab)

Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2

Parekh, Puja K, Logan RW, Ketchesin KD, Becker-Krail D, Shelton MS, Hildebrand MA, Barko K, Huang YH, and McClung CA. The Journal of Neuroscience, vol. 39, no. 24, Aug. 2019, pp. 4657–4667., doi:10.1523/jneurosci.2233-18.2019.

February 6th, 2020 - J Moy (Gold lab)

Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells

Nickolls Alec R., Lee MM, Espinoza DF, Szczot M, et al. Open Access Cell Press, vol. 30, no. 3, Jan . 2020, pp. 932-946,

February 13th, 2020 - K Clark (Gold lab)

Dorsal Root  Ganglion Macrophages Contribute to Both the Initiation and Persistence of Neuropathic Pain

Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI. Nat Commun. 2020 Jan 14;11(1):264. doi: 10.1038/s41467-019-13839-2.

February 20th, 2020 - R Holland (Ross lab)Sharma, Nikhil, et al.The

Emergence of Transcriptional Identity in Somatosensory Neurons

“The Emergence of Transcriptional Identity in Somatosensory Neurons.” Nature, vol. 577, no. 7790, 2020, pp. 392–398., doi:10.1038/s41586-019-1900-1.

February 27th, 2020 - C Warwick (Koerber/Ross lab)


March 5th, 2020 - J Gedeon (Gold lab)

Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp

Mis, Malgorzata A., et al. The Journal of Neuroscience, vol. 39, no. 3, 2018, pp. 382–392., doi:10.1523/jneurosci.2433-18.2018.

March 12th, 2020 - Spring Break (No Journal Club)

March 19th, 2020 - E Nguyen (Ross lab)

Cancelled - COVID19 preparations

March 26th, 2020 - C Warwick (Ross/Koerber lab)

TACAN Is an Ion Channel Involved in Sensing Mechanical Pain

Beaulieu-Laroche L, Christin M, Donoghue A, Agosti F, Yousefpour N, Petitjean H, Davidova A, Stanton C, Khan U, Dietz C, Faure E, Fatima T, MacPherson A, Mouchbahani-Constance S, Bisson DG, Haglund L, Ouellet JA, Stone LS, Samson J, Smith MJ, Ask K, Ribeiro-da-Silva A, Blunck R, Poole K, Bourinet E, Sharif-Naeini R. Cell. 2020 Mar 5;180(5):956-967.

April 2nd, 2020 - H Bobnar (Kolber lab)

SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKIIα Deacetylation in Central Amygdala

Zhou C, Wu Y, Ding X, Shi N, Cai Y, Pan ZZ. J Neurosci. 2020 Mar 11;40(11):2332-2342. doi: 10.1523.

April 9th, 2020 - T Nelson (Taylor lab)

Synaptic Dynamics of the Feed-forward Inhibitory Circuitry Gating Mechanical Allodynia in Mice

Wang Q, Zhang X, He X, Du S, Jiang Z, Liu P, Qi L, Liang C, Gu N, Lu Y. Anesthesiology. 2020 Feb 19. doi: 10.1097/ALN.0000000000003194. [Epub ahead of print].

April 16th, 2020 - D Ferreira (Seal lab)

Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury

Renthal W, Tochitsky I, Yang L, Cheng Y-C, Li E, Kawaguchi R, Geschwind DH, Woolf CJ. bioRxiv preprint.

April 23rd, 2020 - S Salavatian (Mahajan lab)

Spinal Cord Stimulation With "Conventional Clinical" and Higher Frequencies on Activity and Responses of Spinal Neurons to Noxious Stimuli: An Animal Study.

Li S, Farber JP, Linderoth B, Chen J, Foreman RD. Neuromodulation. 2018 Jul;21(5):440-447. doi: 10.1111/ner.12725

Fall 2019

Aug. 27th 2019 - Koerber

An ultrafast system for signaling mechanical pain in human skin
Nagi SS, Marshall AG, Makdani A, Jarocka E, Liljencrantz J, Ridderström M, Shaikh S, O'Neill F, Saade D, Donkervoort S, Foley AR, Minde J, Trulsson M, Cole J, Bönnemann CG, Chesler AT, Bushnell MC, McGlone F, Olausson H. Sci Adv, 2019. doi: 10.1126/sciadv.aaw1297.

Sept. 3rd 2019 - Dos Santos (Taylor Lab)

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes
Fischer R, Sendetski M, Del Rivero T, Martinez GF, Bracchi-Ricard V, Swanson KA, Pruzinsky EK, Delguercio N, Rosalino MJ, Padutsch T, Kontermann RE, Pfizenmaier K, Bethea JR. PNAS, 2019. 116(34):17045-17050. doi: 10.1073/pnas.1902091116.

Sept. 10th 2019 - Noh (Seal Lab)

Specialized cutaneous Schwann cells initiate pain sensation
Abdo H, Calvo-Enrique L, Lopez JM, Song J, Zhang MD, Usoskin D, El Manira A, Adameyko I, Hjerling-Leffler J, Ernfors P. Science, 2019. 365(6454):695-699. doi: 10.1126/science.aax6452.

Sept. 17th 2019 - Salsovic (Koerber Lab)

Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons
Petitjean H, B Bourojeni F, Tsao D, Davidova A, Sotocinal SG, Mogil JS, Kania A, Sharif-Naeini R. Cell Rep., 2019 Aug 6;28(6):1429-1438.e4. doi: 10.1016/j.celrep.2019.07.048.

Sept. 24th 2019 - Pineda-Farias (Gold Lab)

A neuronal circuit for activating descending modulation of neuropathic pain
Huang J, Gadotti VM, Chen L, Souza IA, Huang S, Wang D, Ramakrishnan C, Deisseroth K, Zhang Z, Zamponi GW. Nat Neurosci. 2019 Oct;22(10):1659-1668. doi: 10.1038/s41593-019-0481-5.

Oct. 1st 2019 - Nelson(Taylor Lab)

Itch Webinar (moderated by Sarah Ross)

Oct. 8th 2019 - Epouhe (Lab)

Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity
Castro J, Harrington AM, Lieu T, Garcia-Caraballo S, Maddern J, Schober G, O'Donnell T, Grundy L, Lumsden AL, Miller PE, Ghetti A, Steinhoff MS, Poole DP, Dong X, Chang L, Bunnett NW, Brierley SM. JCI Insight. 2019 Sep 19. pii: 131712. doi: 10.1172/jci.insight.131712.

Oct. 15th 2019 - Nelson (Taylor Lab)

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch
Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, Goulding M. Cell Rep. 2019 Jul 16;28(3):625-639.e6. doi: 10.1016/j.celrep.2019.06.033.

Oct. 22nd 2019 - SFN

Oct. 29th 2019 - Hartung (Gold Lab)

Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors
Zheng W, Nikolaev YA, Gracheva EO, Bagriantsev SN. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17547-17555. doi: 10.1073/pnas.1910213116.

Nov. 5th 2019 - Smith (Ross Lab)

How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch
Pagani M, Albisetti GW, Sivakumar N, Wildner H, Santello M, Johannssen HC, Zeilhofer HU. Neuron. 2019 Jul 3;103(1):102-117.e5. doi: 10.1016/j.neuron.2019.04.022.

Nov. 12th 2019 - Warwick (Ross/Koerber Lab)

Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements
Paixão S, Loschek L, Gaitanos L, Alcalà Morales P, Goulding M, Klein R. Neuron. 2019 Oct 2. pii: S0896-6273(19)30735-4. doi: 10.1016/j.neuron.2019.08.029.

Nov. 19th 2019 - Clark (Gold Lab)

TRESK K+ Channel Activity Regulates Trigeminal Nociception and Headache
Guo Z, Qiu CS, Jiang X, Zhang J, Li F, Liu Q, Dhaka A, Cao YQ. eNeuro. 2019 Jul 29;6(4). pii: ENEURO.0236-19.2019. doi: 10.1523/ENEURO.0236-19.2019. Print 2019 Jul/Aug.

Dec. 3rd 2019 - Ferriera (Lab)

Stereotyped transcriptomic transformation of somatosensory neurons in response to injury
Nguyen MQ, Le Pichon CE, Ryba N.  Elife. 2019 Oct 8;8. pii: e49679. doi: 10.7554/eLife.49679.

Dec. 10th 2019 - Sheahan (Ross Lab)

Dual and Opposing Functions of the Central Amygdala in the Modulation of Pain
Wilson TD, Valdivia S, Khan A, Ahn HS, Adke AP, Martinez Gonzalez S, Sugimura YK, Carrasquillo Y.  Cell Rep. 2019 Oct 8;29(2):332-346.e5. doi: 10.1016/j.celrep.2019.09.011.

Spring 2019

Jan. 8th 2019 - Tayler Sheahan (Ross Lab)

Identifying the pathways required for coping behaviors associated with sustained pain
Huang T., Lin S-H., Malewicz N.M., Zhang Y., Zhang Y., Goulding M., LaMotte R.H., Ma Q. Nature, 2018.

Jan. 15th 2019 - Jamie Moy (Gold Lab)

The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence
Lee K., Vuong H.E., Nusbaum D.J., Hsiao E.Y., Evans C.J., Taylor A.M.W. Neuropsychopharmacology, 2018. 43:2606-2614.

Jan. 22nd 2019 - Isabella Fuentes (Taylor Lab)

Activation of the integrated stress response in nociceptors drives methylglyoxal-induced pain
Barragan-Iglesias P., Kuhn J., Vidal-Cantu G.C. Salinas-Abarca A.B., Granados-Soto V., Dussor G.O., Campbell Z.T., Price T.J. Pain, 2019. 160(1): 160-171. 

Jan. 29th 2019 - Cynthia Arokiaraj (Seal Lab)

Merkel cells activate sensory neural pathways through adrenergic synapse
Hoffman B.U., Baba Y., Griffith T.N., Mosharov E.V., Woo S-H., Roybal D.D., Karsenty G., Patapoutian A., Sulzer D., Lumkin E.A. Neuron, 2018. 100: 1401-1413.

Feb. 5th 2019 - Sebastian Choi (Ginty Lab) *Special Research Presentation*

Feb. 12th 2019 - Kelly Smith(Ross Lab)

Tac1-expressing neurons in the periaqueductal gray facilitate the itch-scratching cycle via descending regulation
Gao Z-R., Chen W-Z., Liu M-Z., Chen X-J., Wan L., Zhang X-Y., Yuan L., Lin J-K., Wang M., Zhou L., Xu X-h., Sun Y-G. Neuron, 2018. 101: 45-59.

Feb. 19th 2019 - Sarah Najjar (Albers Lab)

Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction 
Grundy L., Harrington A.M., Castro J., Garcia-Caraballo S., Deiteren A., Madden J., Rychkov G.Y., Ge P., Peters S., Feil R., Miller P., Ghetti A., Hannig G., Kurtz C.B., Silos-Santiago I., Brierley S.M . JCI Insight, 2018. 3(19):e121841..

Feb. 26th 2019 - Jeremy Gedeon (Dong Lab)

Mechanically activated piezo channels mediate touch and suppress acute mechanical pain response in mice
Zhang M., Wang Y., Geng J., Zhou S., Xiao B . Cell Reports, 2019. 26, 1419-1431.

March 5th 2019 - Michael Chiang (Ross Lab)

A mast-cell-specific receptor mediates neurogenic inflammation and pain 
Green D.P., Limjunyawong N., Your N., Pundir P., Dong X . Neuron, 2019. 101,412-420.

March 12th 2019 - Spring Break 

March 19th 2019 - Andy Cooper (Taylor Lab)

An amygdalae neural ensemble that codes the unpleasantness of pain
Corder G., Ahanonu B., Grewe B.F., Wang D., Schnitzer M.J., Scherrer G. Science, 2019. 363,276-

April 2nd 2019 - Spring Pain - APS Meetings 

April 9th 2019 - Kim Meerschaert (Davis Lab)

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-couple receptor D
Bautzova T., Hockley J.R.F., Perez-Berezo T., Pujo J., Tranter.M.M., Desormeaux C., Barbaro M.R., Basso L., LeFaouder P., Rolland C., Malapert P., Moqrich A., Eutamene H., Denadai-Souza A., Vergnolle N., St John Smith E., Hughes D.I., Barbara G., Dietrich G., Bulmer D.C., Cenac N.  Sci. Signal, 2018. 11,eaal2171.

April 16th 2019 - Heather Allen (Kolber Lab)

A subpopulation of amygdala neurons mediates the affective component of itch
Sanders K.M., Sakai K., Henry T.D., Hashimoto T., Akiyama T.  J Neurosci, 2019. 2759-18 (in press).

April 23rd 2019 - Karen Clark (Gold Lab)

Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity
Akerman S., Karsan N., Bose P., Hoffman J.R., Holland P.R., Romero-Reyes M., Goadsby P.J.  Brain, 2019. 142; 103-119

Fall 2018

Aug. 28th 2018 - Brad Taylor

Functional divergence of delta and mu opioid receptor organization in CNS pain circuits
Wang W., Tawfik V.L., Corder G., Low S.A., Francois A., Basbaum A., Scherrer G. Neuron, 2018. 98:90-108.

Sept. 4th 2018 - Kristen Smith-Edwards (Davis lab)

A population of gut epithelial enterochromaffin cells is mechxnosensitive and requires Piezo2 to convert force into serotonin release
Alcaino C., Knutson K.R., Treichel A.J., Yildiz G., Strege P.R., Linden D.R., Li J.H., Leiter A.B., Szurszewski J.H., Farrugia G., Beyder A. PNAS, 2018. 115(32):E7632-E7641.

Sept. 18th 2018 - Cynthia Arokiaraj (Seal lab)

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
Ding H., Kiguchi N., Yasuda D., Daga P.R., Polgar W.E., Lu J.J., Czoty P.W., Kishoka S., Zaverei N.T., Ko M-C. Sci. Transl. Med., 2018. 10(456) eaar3483.

Sept. 25th 2018 - Sarah Najjar (Albers lab)

Single-cell RNAseq reveals seven classes of colonic sensory neuron
Hockley J.R.F., Taylor T.S., Callejo G., Wilbrey A.L., Gutteridge A., Bach K., Winchester W.J., Bulmer D.C., McMurray G., St John Smith E. Gut  Epub ahead of print 2018.0:1-12.

Oct. 2nd 2018 - Emanuel Loeza (Gold lab)

GABAa receptor subtypes regulates stress-induced colon inflammation in mice
Seifi M., Rodaway S., Rudolph U., Swinny J.D. Gastroenterology   2018. 155(3):852-864.

Oct. 9th 2018 - Kelly Smith (Ross lab)

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections
Liu Y., Latremoliere A., Li X., Zhang Z., Chen M., Wang X., Fang C., Zhu J., Alexandre C., Gao Z., Chen B., Ding X., Zhou J-Y., Zhang Y., Chen C., Wang K.H., Woolf C.J.,m He Z. Nature    2018. 561: S47-S50.

Oct. 16th 2018 - Karen Clark (Gold lab)

Macrophage angiotensin II type 2 receptor triggers neuropathic pain
Shepherd A.J., Mickle A.D., Golden J.P., Mack M.R., Halabi C.M., de Kloet A.D., Samineni V.K., Kim B.S., Krause E.G., Gereau R.W., Mohaptra D.P. PNAS    2018. 115 (34): E805-E8066.

Oct. 30th 2018 - Tyler Nelson (Taylor lab)

NMDA receptor activation underlies the loss of spinal dorsal horn neurons and the transition to persistent pain after peripheral nerve injury
Inquimbert P., Moll M., Latremoliere A., Tong C-K., Zhang J., Sheehan G.F., Smith B.M., Korb E., Athie M.C.P., Babaniyi O., Ghasemlou N., Yanagawa Y., Allis C.D., Hof P.R., Scholtz J . Cell Reports     2018. 23: 2678-2689.

Nov. 13th 2018 - Joe Salsovic (Koerber lab)

Optogenetic activation of non-nociceptive Ab fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats
Tashima R., Koga K., Sekine M., Kanehisa K., Kohro Y., Tominaga K., Matsushita K., Tozaki-Saitoh H., Fukazawa Y., Inoue K., Yaw H., Furue H., Tsuda M. eNeuro   2018. 5(1): 1-14.

Nov. 27th 2018 - Charles Warwick (Koerber/Ross lab)

PIEZO2 mediates injury-induced tactile pain in mice and humans
Szczot M., Liljencrantz J., Ghitani N., Barik A., Lam R., Thompson J.H., Bharucha-Goebel D., Saade D., Necaise A., Donkervoort S., Foley A.R,, Gordon T., Case L., Bushnell M.C., Bonnemann C.G., Chesler A.T. Sci. Transl. Med.   2018. 10 October.

Dec. 4th 2018 - Kim Meerschaert (Davis lab)

A gut-brain neural circuit for nutrient sensory transduction
Kaelberer M.M., Buchanan K.L., Klein M.E., Barth B.B., Montoya M.M., Shen X., Bohorquez D.V. Science.   2018. 361, eaat5236.

Dec. 11th 2017 - Eileen Nguyen (Ross lab)

A brainstem-spinal circuit controlling nocifensive behavior
Barik A., Thompson J.H., Seltzer M., Ghitani N., Chesler A.T. Neuron.   2018. 100: 1-13.

Spring 2018

Jan. 9th 2018 - Brian Davis

Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing
Nguyen M.Q., Wu Y., Bonilla, L.S., von Buchholtz  L.J., Ryba N.J.P. PLoS ONE, 2017. 12(9): 1-22.

Jan. 16th 2018 - Jane Hartung (Gold Lab)

A craniofacial-specific monosynaptic circuit enables heightened affective pain
Rodriguez E., Sakurai K., Xu J., Chen Y., Toda K., Zhao S., Han B-X., Ryu D., Yin H., Liedtke W., Wang F. Nature Neurosci., 2017. 20: 1734-1743.

Jan. 23rd 2018 - CANCELLED (Department of Neurobiology Seminar)

Jan. 30th 2018 - Michael Chiang (Ross Lab)

Keratinocytes mediate innocuous and noxious toch via ATP-P2X4 signalling
Moehring F., Cowie A.M., Menzel A.D. Weyer A.D., Grzybowski M., Arzua T., Geurts A.M., Polygin O., Stuck C.L. eLife, 2018. 7:e31684.

Feb. 6th 2018 - Lillian Laemmle (Kinchington Lab)

Over expression of u-opioid receptors in peripheral afferents, but not in combination with enkephalin, decreases neuropathic pain behavior and enhances opined analgesia in mice
Klein A.H., Mohammad H.K., Ali R., Peper B., Wilson S.P., Raja S.N., Ringkamp M., Schweitzer S.  Anesthesiology - Pain Medicine , 2018. epub.

Feb. 13th 2018 - Brian Edwards (Davis Lab)

Microbiota regulates visceral pain in the mouse
Luczynski P., Tramullas M., Viola M., Shanahan F., Clarke G., O'Mahony S., Dinan T.G., Cryan JF.  eLife, 2017;6:e25887.

Feb. 20th 2018 - Joe Salsovic (Koerber Lab)

Functional and molecular characterization of mechanoinsensitive "silent" nociceptors
Prato V., Taberner F.J., Hockley J.R.F., Callejo G., Arcourt A., Tazir B., Hammer L., Schad P., Heppenstall P.A., Smith E.S., Lechner S.G.  Cell Reports, 2017; 21, 3102-3115.

Feb. 27th 2018 - Sarah Najjar (Albers Lab)

Protease-mediated suppression of DRG neuron excitability by commensal bacteria
Sessenwein J.L., Baker C.C., Pradhananga S., Maitland M.E., Petrof E.O., Allen-Varcoe E., Noordhof C., Reed D.E., Vanner S.J., Lomax A.E.  J Neurosci, 2017; 37(48): 11758-11768.

March 6th 2018 - Spring Break

March 13th 2018 - Jillian Weeks (Sved Lab)

Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer
Watanabe M., Narita M., Hamada Y., Yamashita A., Tamura H., Ikegami D., Kondo T., Shinzato T., Shimizu T., Fukuchi Y., Muto A., Okano H., Yamanaka A., Tawfik V.L., Kuzumaki N., Navratilova E., Porreca F., Narita M.  Molecular Pain, 2018; 14: 1-11.

March 20th 2018 - Cynthia Arokiaraj (Seal Lab)

Massively parallel single nucleus transcriptional profiling defines spinal cord neurons and their activity during behavior
Sathyamurthy A., Johnson K.R., Matson K.J.E., Dobrott C.I., Li L., Ryba A.R., Bergman T.B., Kelly M.C., Kelley M.W., Levine A.J. Cell Reports, 2018; 22: 2216-2225.

March 27th 2018 - Kim Meerschaert (Davis Lab)

Nociceptor sensory neurons suppress neutrophil and gamma/delta T cell responses in bacterial lung infections and lethal pneumonia
Barrel P., Umans B.D., Li L., Wallrapp A., Bist M., Kirschbaum T., Wei Y., Zhou Y., Kuchroo V.K., Burkett P.R., Yipp B.G., Liberles S.D., Chiu I.M. Nature Medicine, 2018; published online March 5.

April 3rd 2018 -Andy Cooper (Taylor Lab)

A neural circuit for the suppression of pain by a competing need state
Alhadeff A.L., Su Z., Hernandez E., Klima M.L., Phillips S.Z., Holland R.A., Gut C., Hantman A.W., De Jonghe B.C., Bentley J.N. Cell, 2018; 173, 140-152.

April 10th 2018 - David Ferreira (Seal Lab)

Mechanistic differences in neuropathic pain modalities revealed by correlating behavior with global expression profiling
Cobos EJ., Nickerson C.A., Gao F., Chandra V., Bravo-Caparros I., ....., Rangachari M., Woolf C.J., Costigan M. Cell Reports, 2018; 22, 1301-1312.

April 17th 2018 - Tayler Sheahan (Ross Lab)

Circuit dissection of the role of somatostatin in itch and pain
Huang J., Polar E., Solinski H. J., Mishra S.K., ......, Zeilhofer H.U., Watanabe M., Riddell J.S., Todd A.J., Hoon, M.A. Nature Neurosci., 2018; (Epub ahead of print) 

April 24th 2018 - Jamie Moy (Gold Lab)

DRG voltage-gated sodium channel 1.7 is upregulated in paclitaxel-induced neuropathy in rats and humans with neuropathic pain
Li Y., North R.Y., Rhines L.D., Esteves Tatsui C., Rao G., Edwards D.D., Cassidy R.M., Harrison D.S., Johansson C.A., Zhang H. Dougherty P.M. J Neurosci., 2018; 38(5):1124-1136.

Fall 2017

Aug. 29th 2017 - Sarah Ross

Specialized mechanosensory nociceptors mediating rapid response to hair pull
Ghitani N, Barik A, Szczot M, Thompson JH, Li C, Le Pichon CE, Krashes, MJ and Chesler, AT. Neuron, 2017. 95: p. 944-54.
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Sept. 5th 2017 - Jane Hartung (Gold lab)

Epiregulin and EGFR interactions are involved in pain processing
Martin, L. J., S. B. Smith, A. Khoutorsky, C. A. Magnussen, A. Samoshkin, R. E. Sorge, C. Cho, N. Yosefpour, S. Sivaselvachandran, S. Tohyama, T. Cole, T. M. Khuong, E. Mir, D. G. Gibson, J. S. Wieskopf, S. G. Sotocinal, J. S. Austin, C. B. Meloto, J. H. Gitt, C. Gkogkas, N. Sonenberg, J. D. Greenspan, R. B. Fillingim, R. Ohrbach, G. D. Slade, C. Knott, R. Dubner, A. G. Nackley, A. Ribeiro-da-Silva, G. G. Neely, W. Maixner, D. V. Zaykin, J. S. Mogil and L. Diatchenko. Journal of Clinical Investigation, 2017. in press.
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Sept. 12th 2017 - Colleen Cassidy (Koerber lab)

Distinct behavioral responses evoked by selective optogenetic stimulation of major TRPV1+ and MrgD+ subsets of C-fibers
Beady H., Daou I., Ase A.R., Ribeiro-de-Silva A., Seguela P. Pain, 2017. in press.

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Sept. 19th 2017 - Cancelled

Sept. 26th 2017 - Jami Saloman (Davis lab)

Gut microbiota is critical for the induction of chemotherapy-induced pain
Shen S., Lim G., You Z., Ding W., Huang P., Ran C., Doheny J., Caravan P., Tate S., Hu K., Kim H., McCabe M., Huang B., Xie Z., Kwon D., Chen L.,Mao J. Nature Neurosci, 2017. 20 (9): 2013-18.

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Oct. 3rd 2017 - Sarah Najjar (Albers lab)

Enterochromaffin cells are gut chemosensory that couple to sensory neural pathways
Bellano N.W., Bayrer J.R., Leitch D.B., Castro J., Zhang C., O'Donnell T.A., Brierley S.M., Ingraham H.A, Julius D. Cell, 2017. 170: 185-198.

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Oct. 10th 2017 - Cynthia Arokiaraj (Seal lab)

A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity
Tan L.L., Pelter P., Heinl C., Tang W., Gangadharan V., Flor H., Sprengel R., Kuner T., Kuner R. Nature Neurosci., 2017. Advanced online publication.

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Oct. 17th 2017 - Jorge Pineda (Gold lab)

miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
Peng C., Li L., Zhang M.D., Gonzales C.B., Parisien M., Belfer I., Usoskin D., Abdo H., Furlan A., Haring M., Lallemand F., Harkany T., Diatchenko L., Hokfelt T., Hjerling-Leffler J., Ernfors P. Science, 2017, 356: 1168-1171. 

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Oct. 24th 2017 - Stephanie Puig (Gutstein lab)

Site-specific regulation of P2X7 receptor function in microglia gates morphine analgesic tolerance
Leduc-Pessah H., Weilinger N.L., Fan C.Y., Burma N.E., Thompson R.J., Trang T. J Neurosci, 2017, Advanced online publication. 

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Oct. 31st 2017 - Joe Salsovic (Koerber lab)

Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source
Weir G.A., Middleton S.J., Clark A.J., Daniel, T., Khovanov N., McMahon S.B., Bennett D.L. Brain, 2017: 140, 2570-2585.

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Nov. 7th 2017 - Kristen Smith Edwards (Davis lab)

Ex vivo study of human visceral nociceptors
McGuire C., Boundouki G., Hockley J.R.F., Reed D., Cibert-Goton V., Peiris M., Kung V., Broad J., Aziz Q., Chan C., Ahmed S., Thaha M.A., Sanger G.J., Blackshaw L.A., Knowles C.H., Bulmer D.C. Gut, 2016; 0:1-11

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Nov. 14th 2017 - SFN week

Nov. 21st 2017 - Thanksgiving break

Nov. 28th 2017 - Emanuel Loeza (Gold lab)

α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors
Castro J., Harrington A.M., Garcia-Caraballo S., Maddem J., Grundy L., Zhang J., Page G., Miller P.E., Craik D.J., Adams D.J., Brierley S.M. Gut, 2017;66:1083-1094.

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Dec. 5th 2017 - Jillian Weeks (Sved lab)

Nicotinic modulation of descending pain control circuitry
Umana I.C., Daniele C.A., Miller B.A., Abburi C., Gallagher K., Brown M.A., Mason P., McGehee D.S. Pain, 2017; 158:1938-1950. 

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Dec. 12th 2017 - Junichi Hachisuka (Ross lab)

A central neural circuit for itch sensation
Mu D., Deng J., Ke-Fei L., Wu Z-Y., Shi Y-F., Guo W-M., Mao Q-Q., Liu X-J., Li H., Sun Y-G. Science, 2017; 357:695-699. 

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Spring 2017

Jan. 3rd 2017 - John Horn

The sacral autonomic outflow is sympathetic
Espinosa-Medina I, Saha O, Boismoreau F, Chettouh Z, Rossi F, Richardson WD and Brunet JF. Science, 2016. 354(6314): p. 893 - 7.
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consensus: developmental biologists and physiologists come head-to-head!
discussion from this journal club led to an eLetter response in Science.

Jan. 10th 2017 - Cedric Peirs (Seal lab)

Touch receptor-derived sensory information alleviates acute pain signaling and fine-tunes nociceptive reflex coordination
Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA and Lechner SG. Neuron, 2016. in press
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consensus: very cool paper and outstanding presentation. double kudos!

Jan. 17th 2017 - Qing Liu

Spinal inhibitory interneuron diversity delineate variant motor microcircuits
Bikoff J, Gabito MI, Rivard AF, Drobac E, Machado TA, Miri A, Brenner-Morton S, Famojure E, Diaz C, Alvarez FJ, Mentis GZ, and Jessel TM. Cell, 2016. 165(1) 207-219
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consensus: so many subtypes!

Jan. 24th 2017 - Keith Vogt

Different brain circuitries mediating controllable and uncontrollable pain
Brasher AK, Becker S, Hoeppli ME, Schweinhardt P. J Neurosci, 2016. 38(18):5013-5020
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consensus: this is an important question

Jan. 31st 2017 - Stephanie Puig (Gutstein Lab)

Loss of mu opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia
Corder G, Tawfik VL, Sypek EI, Low SA, Dickinson JR,Sotoudeh C, Clark JD, Barres, BA, Bohlen CJ, and Scherrer G. Nat Medicine, 2017.published online Jan. 16.
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consensus: so interesting -- lots of discussion!

Feb. 7th 2017 - Emanuel Loeza (Gold lab)

Reversible induction of pain hypersensitivity following ontogenetic stimulation of spinal astrocytes
Nam Y, Kim J-H, Kim J-H, Jha MK, Jung JY, Lee M-G, Choi I-S, Jang I-S, Lim DG, Hwang S-H, Cho H-J, Suk K. Cell Reports, 2016. 17, 3049-3061
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consensus: nice job Emanuel!

Feb. 14th 2017 - Tara Deemyad (Urban lab)**

Shank3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons
Han Q, Kin YH, Wang X, Liu D, Zhang Z-J, Bey AL, Lay M, Chang W, Berta T, Zhang Y, Jiang Y-H, Ji RR. Neuron, 2016. 92, 1279-1293
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consensus: novel presynaptic function for Shank!

Feb. 21st 2017 - Lindsey Snyder (Ross lab)

A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins
Francois A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Ritola KD, Shariff-Naeini R, Deiseroth K, Delp SL,Malenka RC, Juo,L, Hantman AW, and Scherrer G. Neuron, 2017. 93, 1-18
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consensus: Tour de force highlighting cool viral experiments

Feb. 28th 2017 - Jane Hartung (Gold lab)

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents
Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Mousseau M, Shankar JV, Stemkowski PL, Baimoukhametova D, Bains JS, Antle MC, Zamponi GW, Cahill CM, Borgland SL, De Koninck Y, Trang T. Nat Medicine, 2017. Jan 30 [Epub ahead of print]
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consensus: Intriguing results sparked a heated debate over the presence of opioid receptors in glial cells.

March 7th 2017 - Spring Break

March 14th 2017 - Michael Chiang (Ross lab)**

Leaky gate model: Intensity-dependent coding of pain and itch in the spinal cord
Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Neuron, 2017. 93, 840-853.
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consensus: this was the most hilarious journal club ever.

March 21st 2017 - Sarah Najjar (Albers lab)

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats
Ibrahim MM, Patwardhan A, Galbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Pain, 2017. 158 (2), 347-360.
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consensus: wow! this is very intriguing, and a huge caution for all of us doing real time place aversion with light.

March 28th 2017 - Jami Soloman (Davis lab)

PanIN neuroendocrine cells promoter tumorigenesis via neuronal crosstalk
Sinha S, Fu Y, Grimont A, Ketcham, M, Lafaro K, Saglimbeni JA, Askan G, Bailey JM, Melchior JP, Zhong Y, Joo MG, Grbovic-Huezo O, Yang IH, Basturn O, Baker L, Park Y, Kurtz RC, Tuveston D, Leach SD and Pasricha PJ. Cancer Research 2017. in press.
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consensus: cool insight into the mystery of neural-epithelial crosstalk in cancer — substance P!

April 4th 2017 - Colleen Cassidy (Koerber lab)

Small-molecule inhibition of STOML3 oligomerization reverses pathological hypersensitivity
Wetzel C, Pilfer S, Picci C, Gok C, Hoffman D,Bali KK, Lampe A,Lapatsina L, Fleischer R, St John Smith E, Begay V, Moroni M, Estebanez L, Kuhnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Tuner R, Poulet JFA, Schmoranger J, Poole K and Lewin G. Nature Neuroscience 2017. 20(2), 209-218.
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April 11th 2017 - Junichi Hachisuka (Ross lab)

Molecular and neural basis of contagious itch behavior in mice
Yu YQ, Barry DM, Hao Y, Liu XT, Chen ZF. Science 2017. 355, 1072-1076.
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consensus: the optogenetic data are pretty compelling -- who would of guessed that the SCN is involved in itch?

April 18th 2017 - Distinguished Speaker Lunch

April 25th 2017 - Cynthia Arokiaraj (Seal lab)

Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission
Du X,Hao H,Yang Y, Huang, S, Wang C, Gigot S, Ramli R, Li X, Jaworski E, Edwards I, Deuchars J, Yanagawa Y, QI J, Guan B, Jaffe DB, Zhang H, Gamper N. J Clin Invest 2017. April 4. [Epub ahead of print].
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Fall 2016

Aug. 30th 2017 - Maggie Wright (Koerber lab)

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
Osteen, J.D., V. Herzig, J. Gilchrist, J.J. Emrick, C. Zhang, X. Wang, J. Castro, S. Garcia-Caraballo, L. Grundy, G.Y. Rychkov, A.D. Weyer, Z. Dekan, E.A.B. Undheim, P. Alewood, C.L. Stucky, S.M. Brierley, A.I. Basbaum, F. Bosmans, G.F. King, and D. Julius. Nature, 2016. 534(7608): p. 494-499.
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  consensus: watch out for those spiders - fantastic presentation Maggie of a very interesting paper!

Sept. 6th 2016 - Jami Saloman (Davis lab)

Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain
Xie, W., S. Chen, J. A. Strong, A. L. Li, I. P. Lewkowich and J. M. Zhang The Journal of neuroscience 2016.36(33): 8712-8725.
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  consensus: microsympa-wow! tricky surgery. very impressive!

Sept. 13th 2016 - Michael Chiang (Ross lab)

The coding of cutaneous temperature in the spinal cord
Ran C, Hoon MA, Chen X Nat Neurosci.  2016 Sep; 19(9):1201-9.
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  consensus: such an exciting proof of concept -- this is the future of understanding spinal microcircuits

Sept. 20th 2016 - Matt Rannals (Urban lab)**

GABA-b receptors tune cortical feedback to the olfactory bulb
Maza C, Lepousez, G, Nissant A, Valley MT and Lledo PM,  Nat Neurosci.  2016 Aug; 36(32):8289-8304.
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  consensus: nice job Matt, teasing apart the function of a particular synapse in top-down control!

Sept. 27th 2016 - Sarah Najjar (Albers lab)

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain
Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spray DC, Dong X. Neuron, 2016. 91(5): p. 1085-96.
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  consensus: excitatory communication between neurons generated excited communication among scientists.
Sarah, your journal club generated an outstanding discussion!

Oct. 4th 2016 - Cedric Peirs (Seal lab)

Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain
Cui L, Miao X, Liang L, Abdus-Saboor I, Olson W, Flemming MS, Ma M, Tao Y, Luo W. Neuron, 2016. 91(5): p. 1137-53.
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  consensus: these are some really powerful inhibitory interneurons!

Oct. 11th 2016 - Jorge Pineda (Gold lab)

The TRPM2 ion channel is required for sensitivity to warmth
Tan CH and Mcnaughton PA. Nature, 2016. 460(536).
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  consensus: we are feeling warm all over -- cool new heat transducer

Oct. 18th 2016 - Stephanie Puig (Gutstein lab)

GRK2 constitutively governs peripheral delta opioid receptor activity
Brackley, AD, Gomez, R, Akopian AN, Henry MA and Jeske NA. Cell Report, 2016. 16(2686).
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  consensus: location, location, location!

Oct. 25th 2016 - Colleen Cassidy (Koerber lab)

Merkel disc is a serotonergic synapse in the epidermis for transmitting tactile signals in mammals
Chang W, Kanda H, Ikeda, R, Ling J, De Berry, JJ, Gu JG PNAS, 2016. 113(37) E5491.
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  consensus: I like the feel of this!

Nov. 1st 2016 - Lindsey Snyder (Ross lab) **

Mapping sub-second structure in mouse behavior
Wiltschko AB, Johnson MG, Iurilli G, Peterson ER, Katon JS, Pashkovski SL, Abraira VE, Adams RP and Datta SR Neuron, 2015. 88(1121).
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  consensus: Great Journal Club! Can't wait to see improvements enabling the

Nov. 8th 2016 - Melissa Giraldo Duque (Gold lab)

Social transfer of pain in mice
Smith ML, Hostetler CM, Heinricher MM, Ryabinin AE Science Advances, 2016. 2(10):e1600855.
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  consensus: sensitive creatures!

Nov. 15th 2016 - SfN week

Nov. 22nd 2016 - Thanksgiving week

Nov. 29th 2016 - Marissa Kuzirian (Ross lab)

Capturing and manipulating activated neuronal ensembles with CANE delineates a hypothalamic social-fear circuit
Sakurai K, Zhao S, Takatoh J, Rodriguez E, Lu J, Leavitt AD, Fu M, Han BX and Wang F Neuron, 2016. 92(1).
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  consensus: this paper was outstanding! What an awesome new tool!

Dec. 6th 2016 - Junichi Hachisuka (Ross lab)

In vivo interrogation of spinal mechanosensory circuits
Christensen AJ, Iyer SM, Francois A, Vyas S, Ramakrishnan C, Vesuna S, Deisseroth K, Scherrer G and Delp SL Cell Reports, 2016. 17(6)1699.
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  consensus: we're lighting up with excitement over this one!

Dec. 13th 2016 - Jane Hartung (Gold lab)

In vivo characterization of distinct modality-specific subsets of somatosensory neurons using GCaMP
Emery EC, Liuz, AP, Sikander S, Magnusdottir R, Dong X, Wood JN Science Advances, 2016. 2:e1600990.
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  consensus: surprisingly controversial. Wow!
  discussion from this journal club led to a heated debate 

Pain Research Forum