Stay current with advances in the field of pain research! The Pain Journal Club meets weekly during the fall and spring semesters to discuss cutting edge papers about pain, from mechanisms to circuitry. Presentations are made by Pain Center trainees (graduate student and postdocs) but the emphasis is on interactive discussions. All are welcome to attend. Students are welcome to take this as a one-credit class (MSNBIO 2651). Meetings are Tuesdays at noon in BST 1495. For more information, or if you would like to be able to virtually attend these meetings, contact Sarah Ross (saross@pitt.edu) or Brad Taylor (bkt@pitt.edu).
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Current Journal Club Schedule: Fall 2022
Sept. 8 Ariel Epouhe (Albers lab)
A brainstem map for visceral sensations.
Ran C, Boettcher JC, Kaye JA, Gallori CE, Liberles SD. Nature. 2022 Aug 31. doi: 10.1038/s41586-022-05139-5. Online ahead of print. PMID: 36045291
Sept. 15 Lisa McIlvried (Scheff lab)
Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons.
Yang NJ, Isensee J, Neel DV, Quadros AU, Zhang HB, Lauzadis J, Liu SM, Shiers S, Belu A, Palan S, Marlin S, Maignel J, Kennedy-Curran A, Tong VS, Moayeri M, Röderer P, Nitzsche A, Lu M, Pentelute BL, Brüstle O, Tripathi V, Foster KA, Price TJ, Collier RJ, Leppla SH, Puopolo M, Bean BP, Cunha TM, Hucho T, Chiu IM. Nat Neurosci. 2022 Feb;25(2):168-179. doi: 10.1038/s41593-021-00973-8. Epub 2021 Dec 20. PMID: 34931070
Sept. 22 -- cancelled IASP
Sept. 29 Kelly Smith (Ross lab)
Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions.
Liu S, Ye M, Pao GM, Song SM, Jhang J, Jiang H, Kim JH, Kang SJ, Kim DI, Han S. Neuron. 2022 Mar 2;110(5):857-873.e9. doi: 10.1016/j.neuron.2021.11.029. Epub 2021 Dec 17. PMID: 34921781
Oct. 6 Alex Lee (Seal lab)
The role of somatosensory innervation of adipose tissues.
Wang Y, Leung VH, Zhang Y, Nudell VS, Loud M, Servin-Vences MR, Yang D, Wang K, Moya-Garzon MD, Li VL, Long JZ, Patapoutian A, Ye L. Nature. 2022 Sep;609(7927):569-574. doi: 10.1038/s41586-022-05137-7. Epub 2022 Aug 31. PMID: 3604528Oct 13 Matias Preisegger (Gold lab)
Oct 20 Abby Hellman (Taylor lab)
Oct 27 Jeremy Gedeon (Gold lab)
Nov 3 Abby Cui (Ross lab)
Nov 10 Adam Brandner (Farris and Taylor labs)
Nov 17 -- cancelled SfN
Dec 1 Isabel Bleimester (Ross lab)
Dec 8 Kenny Roman (Roman lab)
Previous Journal Club Schedules
Spring 2022
Jan 13 - Charlie Warwick (Ross/KoerberLab)
Decoding Cellular Mechanisms for Mechanosensory Discrimination.
von Buchholtz LJ, Ghitani N, Lam RM, Licholai JA, Chesler AT, Ryba NJP. Neuron. 2021 Jan 20;109(2):285-298.e5. doi: 10.1016/j.neuron.2020.10.028. Epub 2020 Nov 12. PMID: 33186546
Jan 20 - Sydney Lamerand (Taylor Lab)
Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states.
Zhu X, Tang HD, Dong WY, Kang F, Liu A, Mao Y, Xie W, Zhang X, Cao P, Zhou W, Wang H, Farzinpour Z, Tao W, Song X, Zhang Y, Xue T, Jin Y, Li J, Zhang Z. Nat Neurosci. 2021 Apr;24(4):542-553. doi: 10.1038/s41593-021-00811-x. Epub 2021 Mar 8. PMID: 33686297
Jan 27 - Jane Hartung (Gold Lab)
Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice.
Middleton SJ, Perini I, Andreas C T, Weir GA, McCann K, Barry AM, Marshall A, Lee M, Mayo LM, Bohic M, Baskozos G, Morrison I, Löken LS, McIntyre S, Nagi SS, Staud R, Sehlstedt I, Johnson RD, Wessberg J, Wood JN, Woods CG, Moqrich A, Olausson H, Bennett DL. Brain. 2021 Dec 27:awab482. doi: 10.1093/brain/awab482. Online ahead of print. PMID: 34957475
Feb 3 - Ruby Holland (Ross Lab)
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior.
Markovic T, Pedersen CE, Massaly N, Vachez YM, Ruyle B, Murphy CA, Abiraman K, Shin JH, Garcia JJ, Yoon HJ, Alvarez VA, Bruchas MR, Creed MC, Morón JA. Nat Neurosci. 2021 Nov;24(11):1601-1613. doi: 10.1038/s41593-021-00924-3. Epub 2021 Oct 18. PMID: 34663957
Feb 10 - Tayler Sheahan (Ross Lab)
Glutamate in primary afferents is required for itch transmission.
Cui L, Guo J, Cranfill SL, Gautam M, Bhattarai J, Olson W, Beattie K, Challis RC, Wu Q, Song X, Raabe T, Gradinaru V, Ma M, Liu Q, Luo W. Neuron. 2021 Dec 30:S0896-6273(21)01015-1. doi: 10.1016/j.neuron.2021.12.007. Online ahead of print. PMID: 34986325
Feb 17 - Ariel Epouhe (Albers Lab)
Blocking peripheral drive from colorectal afferents by sub-kilohertz dorsal root ganglion stimulation.
Chen L, Guo T, Zhang S, Smith PP, Feng B. Pain. 2021 Jul 2:10.1097/j.pain.0000000000002395. doi: 10.1097/j.pain.0000000000002395. Online ahead of print. PMID: 34232925
24-Feb Heather Allen (Taylor Lab)
A distinct parabrachial-to-lateral hypothalamus circuit for motivational suppression of feeding by nociception.
Phua SC, Tan YL, Kok AMY, Senol E, Chiam CJH, Lee CY, Peng Y, Lim ATJ, Mohammad H, Lim JX, Fu Y. Sci Adv. 2021 May 7;7(19):eabe4323. doi: 10.1126/sciadv.abe4323. Print 2021 May. PMID: 33962958
Mar 3 - Kayla Nguyen (Taylor Lab)
Postinjury stimulation triggers a transition to nociplastic pain in mice.
Hankerd K, McDonough KE, Wang J, Tang SJ, Chung JM, La JH. Pain. 2022 Mar 1;163(3):461-473. doi: 10.1097/j.pain.0000000000002366. PMID: 34285154
Mar 10 - Spring Break
Mar 17 - Jeremy Gedeon (Gold Lab)
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors.
Tavares-Ferreira D, Shiers S, Ray PR, Wangzhou A, Jeevakumar V, Sankaranarayanan I, Cervantes AM, Reese JC, Chamessian A, Copits BA, Dougherty PM, Gereau RW 4th, Burton MD, Dussor G, Price TJ. Sci Transl Med. 2022 Feb 16;14(632):eabj8186. doi: 10.1126/scitranslmed.abj8186. Epub 2022 Feb 16. PMID: 35171654
Mar 24 - Andrew Liu (Kaplan Lab)
Insular cortex neurons encode and retrieve specific immune responses.
Koren T, Yifa R, Amer M, Krot M, Boshnak N, Ben-Shaanan TL, Azulay-Debby H, Zalayat I, Avishai E, Hajjo H, Schiller M, Haykin H, Korin B, Farfara D, Hakim F, Kobiler O, Rosenblum K, Rolls A. Cell. 2021 Nov 24;184(24):5902-5915.e17. doi: 10.1016/j.cell.2021.10.013. Epub 2021 Nov 8. PMID: 34752731
Mar 31 - Problem with paper pick - the first choice had been presented as a BioRxiv paper in 2020
Apr 7 - Meagan Makarcyzk (Lin Lab)
Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain.
van der Vlist M, Raoof R, Willemen HLDM, Prado J, Versteeg S, Martin Gil C, Vos M, Lokhorst RE, Pasterkamp RJ, Kojima T, Karasuyama H, Khoury-Hanold W, Meyaard L, Eijkelkamp N. Neuron. 2022 Feb 16;110(4):613-626.e9. doi: 10.1016/j.neuron.2021.11.020. Epub 2021 Dec 17. PMID: 34921782
Apr 14 - Jami Saloman
Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics.
George DS, Hackelberg S, Jayaraj ND, Ren D, Edassery SL, Rathwell CA, Miller RE, Malfait AM, Savas JN, Miller RJ, Menichella DM. Pain. 2022 Mar 1;163(3):560-578. doi: 10.1097/j.pain.0000000000002391. PMID: 34232927
Apr 21 Sara Trbovjevic (Almarza Lab) Cancelled
Apr 28 Charlie Warwick (Ross and Koerber Labs)
Multiscale Computer Model of the Spinal Dorsal Horn Reveals Changes in Network Processing Associated with Chronic Pain.
Medlock L, Sekiguchi K, Hong S, Dura-Bernal S, Lytton WW, Prescott SA. J Neurosci. 2022 Apr 13;42(15):3133-3149. doi: 10.1523/JNEUROSCI.1199-21.2022. Epub 2022 Mar 1. PMID: 35232767
Fall 2021
Sept 2 - Sydney Lamerand (Taylor Lab)
Central amygdala inflammation drives pain hypersensitivity and attenuates morphine analgesia in experimental autoimmune encephalomyelitis
Dworsky-Fried Z, Faig CA, Vogel HA, Kerr BJ, Taylor AMW. Pain. 2021 Apr 9. doi: 10.1097/j.pain.0000000000002307. Online ahead of print
Sept 9 - Nicole Scheff
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential.
Huang S, Ziegler CGK, Austin J, Mannoun N, Vukovic M, Ordovas-Montanes J, Shalek AK, von Andrian UH. Cell. 2021 Jan 21;184(2):441-459.e25. doi: 10.1016/j.cell.2020.11.028. Epub 2020 Dec 16. PMID: 33333021
Sept 16 - Kelly Smith (Ross Lab)
Pain modulates dopamine neurons via a spinal-parabrachial-mesencephalic circuit.
Yang H, de Jong JW, Cerniauskas I, Peck JR, Lim BK, Gong H, Fields HL, Lammel S. Nat Neurosci. 2021 Aug 9. doi: 10.1038/s41593-021-00903-8. Online ahead of print. PMID: 34373644
Sept 23 - Michael Gold
Two independent mouse lines carrying the Nav1.7 I228M gain-of-function variant display dorsal root ganglion neuron hyperexcitability but a minimal pain phenotype.
Chen L, Wimalasena NK, Shim J, Han C, Lee SI, Gonzalez-Cano R, Estacion M, Faber CG, Lauria G, Dib-Hajj SD, Woolf CJ, Waxman SG. Pain. 2021 Jun 1;162(6):1758-1770. doi: 10.1097/j.pain.0000000000002171. PMID: 33323889
Sept 30 - Ariel Epouhe (Albers Lab)
Local immune response to food antigens drives meal-induced abdominal pain.
Aguilera-Lizarraga J, Florens MV, Viola MF, Jain P, Decraecker L, Appeltans I, Cuende-Estevez M, Fabre N, Van Beek K, Perna E, Balemans D, Stakenborg N, Theofanous S, Bosmans G, Mondelaers SU, Matteoli G, Ibiza Martínez S, Lopez-Lopez C, Jaramillo-Polanco J, Talavera K, Alpizar YA, Feyerabend TB, Rodewald HR, Farre R, Redegeld FA, Si J, Raes J, Breynaert C, Schrijvers R, Bosteels C, Lambrecht BN, Boyd SD, Hoh RA, Cabooter D, Nelis M, Augustijns P, Hendrix S, Strid J, Bisschops R, Reed DE, Vanner SJ, Denadai-Souza A, Wouters MM, Boeckxstaens GE. Nature. 2021 Feb;590(7844):151-156. doi: 10.1038/s41586-020-03118-2. Epub 2021 Jan 13. PMID: 33442055
Oct 7 - Joel Caporoso (Xu Lab)
A Glra3 phosphodeficient mouse mutant establishes the critical role of protein kinase A-dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia.
Werynska K, Gingras J, Benke D, Scheurer L, Neumann E, Zeilhofer HU. Pain. 2021 Sep 1;162(9):2436-2445. doi: 10.1097/j.pain.0000000000002236.
Oct 14 - Alex Lee (Seal Lab)
Mechanoreceptor synapses in the brainstem shape the central representation of touch
Lehnert, BP, Santiago S, Huey EL, Emanuel EJ, Renauld S, Africawala N, Alkislar I, Zheng Y, Bai L, Koutsioumpa C, Hong JT, Magee AR, Harvey CD, Ginty DD. bioRxiv preprint doi: https://doi.org/10.1101/2021.02.02.429463; this version posted February 4, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license.
Oct 21 - Heather Allen (Taylor Lab)
Parabrachial nucleus circuit governs neuropathic pain-like behavior.
Sun L, Liu R, Guo F, Wen MQ, Ma XL, Li KY, Sun H, Xu CL, Li YY, Wu MY, Zhu ZG, Li XJ, Yu YQ, Chen Z, Li XY, Duan S. Nat Commun. 2020 Nov 25;11(1):5974. doi: 10.1038/s41467-020-19767-w.
Oct 28 - Anna Baratta (Farris Lab)
Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice.
De Logu F, Li Puma S, Landini L, Portelli F, Innocenti A, de Araujo DSM, Janal MN, Patacchini R, Bunnett NW, Geppetti P, Nassini R. J Clin Invest. 2019 Dec 2;129(12):5424-5441. doi: 10.1172/JCI128022.
Nov 4 - Sam Noh (Seal Lab)
A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1.7.
MacDonald DI, Sikandar S, Weiss J, Pyrski M, Luiz AP, Millet Q, Emery EC, Mancini F, Iannetti GD, Alles SRA, Arcangeletti M, Zhao J, Cox JJ, Brownstone RM, Zufall F, Wood JN. Neuron. 2021 May 5;109(9):1497-1512.e6. doi: 10.1016/j.neuron.2021.03.012. Epub 2021 Apr 5.
Nov 11 - Haichao Chen (Ross Lab)
An endogenous opioid circuit determines state-dependent reward consumption.
Castro DC, Oswell CS, Zhang ET, Pedersen CE, Piantadosi SC, Rossi MA, Hunker AC, Guglin A, Morón JA, Zweifel LS, Stuber GD, Bruchas MR. Nature. 2021 Oct;598(7882):646-651. doi: 10.1038/s41586-021-04013-0. Epub 2021 Oct 13.
Nov 18 - Chien-Sin Chen (Kaplan Lab)
Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions.
Hoeffel G, Debroas G, Roger A, Rossignol R, Gouilly J, Laprie C, Chasson L, Barbon PV, Balsamo A, Reynders A, Moqrich A, Ugolini S. Nature. 2021 Jun;594(7861):94-99. doi: 10.1038/s41586-021-03563-7. Epub 2021 May 19.
Nov 25 - Thanksgiving
Dec 2 - Tyler Nelson (Talyor Lab)
Astrocytes contribute to pain gating in the spinal cord.
Xu Q, Ford NC, He S, Huang Q, Anderson M, Chen Z, Yang F, Crawford LK, Caterina MJ, Guan Y, Dong X. Sci Adv. 2021 Nov 5;7(45):eabi6287. doi: 10.1126/sciadv.abi6287. Epub 2021 Nov 3.
Dec 9 - Talia Adi (Gold Lab)
Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior.
Powell R, Young VA, Pryce KD, Sheehan GD, Bonsu K, Ahmed A, Bhattacharjee A. Nat Commun. 2021 Oct 4;12(1):5812. doi: 10.1038/s41467-021-26100-6.
Spring 2021
21-Jan Brian Davis
PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1
Chen G, Kim YH, Li H, Luo H, Liu DL, Zhang ZJ, Lay M, Chang W, Zhang YQ, Ji RR. Nat Neurosci. 2017 Jul;20(7):917-926. doi: 10.1038/nn.4571.
28-Jan Andrew Liu (Kaplan Lab)
STING controls nociception via type I interferon signalling in sensory neurons
Donnelly CR, Jiang C, Andriessen AS, Wang K, Wang Z, Ding H, Zhao J, Luo X, Lee MS, Lei YL, Maixner W, Ko MC, Ji RR. Nature. 2021 Jan 13. doi: 10.1038/s41586-020-03151-1. Online ahead of print.
4-Feb Charlie Warwick (Ross/Koerber Lab)
A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior
Tashima R, Koga K, Yoshikawa Y, Sekine M, Watanabe M, Tozaki-Saitoh H, Furue H, Yasaka T, Tsuda M. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2021220118. doi: 10.1073/pnas.2021220118.
11-Feb David Ferreira (Seal Lab)
Single cell transcriptomics of primate sensory neurons identifies cell types associated with human chronic pain
Kupari, J, Usoskin D, Lou D, Parisien M, Hu Y, Fatt M, Lönnerberg P, Spångberg M, Eriksson B, Barkas N, Kharchenko PV, Loré K, Khoury S, Diatchenko L, and Ernfors P (2021) bioRxiv preprint doi: https://doi.org/10.1101/2020.12.07.414193
18-Feb Jane Hartung (Gold Lab)
Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans.
Case LK, Liljencrantz J, Madian N, Necaise A, Tubbs J, McCall M, Bradson ML, Szczot M, Pitcher MH, Ghitani N, Frangos E, Cole J, Bharucha-Goebel D, Saade D, Ogata T, Donkervoort S, Foley AR, Bönnemann CG, Olausson H, Bushnell MC, Chesler AT. Nat Commun. 2021 Jan 28;12(1):657. doi: 10.1038/s41467-021-20939-5.
25-Feb Kayla Nguyen (Taylor Lab)
Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury.
Davoli-Ferreira M, de Lima KA, Fonseca MM, Guimarães RM, Gomes FI, Cavallini MC, Quadros AU, Kusuda R, Cunha FQ, Alves-Filho JC, Cunha TM. Pain. 2020 Aug;161(8):1730-1743. doi: 10.1097/j.pain.0000000000001879. Epub 2020 Mar 26.
4-Mar Tayler Sheahan (Ross Lab)
A spinal neural circuitry for converting touch to itch sensation
Chen S, Gao XF, Zhou Y, Liu BL, Liu XY, Zhang Y, Barry DM, Liu K, Jiao Y, Bardoni R, Yu W, Chen ZF. Nat Commun. 2020 Oct 8;11(1):5074. doi: 10.1038/s41467-020-18895-7.
11-Mar Cynthia Arokiaraj (Seal Lab)
Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury
Niehaus JK, Taylor-Blake B, Loo L, Simon JM, Zylka MJ. 2021 Neuron 109:1-9. doi.org/10.1016/j.neuron.2021.02.018
18-Mar Jeremy Gedeon (Gold Lab)
Keratinocytes Communicate with Sensory Neurons via Synaptic-like Contacts.
Talagas M, Lebonvallet N, Leschiera R, Sinquin G, Elies P, Haftek M, Pennec JP, Ressnikoff D, La Padula V, Le Garrec R, L'herondelle K, Mignen O, Le Pottier L, Kerfant N, Reux A, Marcorelles P, Misery L. Ann Neurol. 2020 Dec;88(6):1205-1219. doi: 10.1002/ana.25912. Epub 2020 Oct 10
25-Mar Sara Trbojevic (Almarza Lab)
Females have greater susceptibility to develop ongoing pain and central sensitization in a rat model of temporomandibular joint pain.
Sannajust S, Imbert I, Eaton V, Henderson T, Liaw L, May M, Barbe MF, King T. Pain. 2019 Sep;160(9):2036-2049. doi: 10.1097/j.pain.0000000000001598.
1-Apr Meagan Makarcyk (Lin Lab)
Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis.
Zhu J, Zhen G, An S, Wang X, Wan M, Li Y, Chen Z, Guan Y, Dong X, Hu Y, Cao X. Elife. 2020 May 22;9:e57656. doi: 10.7554/eLife.57656.
8-Apr Texas Pain Consortium.
15-Apr Ruby Holland (Ross Lab)
Periaqueductal gray/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors.
Yu W, Pati D, Pina MM, Schmidt KT, Boyt KM, Hunker AC, Zweifel LS, McElligott ZA, Kash TL.
Neuron. 2021 Mar 11:S0896-6273(21)00149-5. doi: 10.1016/j.neuron.2021.03.001.
22-Apr Sydney Lamerand (Taylor Lab)
Optogenetic activation of spinal microglia triggers chronic pain in mice.
Yi MH, Liu YU, Umpierre AD, Chen T, Ying Y, Zheng J, Dheer A, Bosco DB, Dong H, Wu LJ. PLoS Biol. 2021 Mar 19;19(3):e3001154. doi: 10.1371/journal.pbio.3001154. eCollection 2021 Mar.
29-Apr Kenny Roman
Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia.
Smith ML, Asada N, Malenka RC. Science. 2021 Jan 8;371(6525):153-159. doi: 10.1126/science.abe3040. Epub 2021 Jan 7.
Previous Journal Club Schedules
Fall 2020
Aug 20th - Eileen Nguyen (Ross Lab)
Orchestrating Opiate-Associated Memories in Thalamic Circuits
Keyes PC, Adams EL, Chen Z, Bi L, Nachtrab G, Wang VJ, Tessier-Lavigne M, Zhu Y, Chen X. Neuron 2020 ;S0896-6273(20)30482-7. doi: 10.1016
Sept 1st - David Ferreira (Seal Lab) - Note this is a Tuesday
Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain
Raoof R, van der Vlist M, Willemen HDLDM, Prado J, Versteeg S, Vos M, Lokhorst RE, Pasterkamp RJ, Khoury-Hanold, W, Meyaard L, Eijkelkamp N. 2020 bioRxiv doi: https://doi.org/10.1101/2020.02.12.940445
Sept 3rd - Jeremy Gedeon (Gold Lab)
Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception.
Neubarth NL, Emanuel AJ, Liu Y, Springel MW, Handler A, Zhang Q, Lehnert BP, Guo C, Orefice LL, Abdelaziz A, DeLisle MM, Iskols M, Rhyins J, Kim SJ, Cattel SJ, Regehr W, Harvey CD, Drugowitsch J, Ginty DD. Science. 2020 Jun 19;368(6497):eabb2751. doi: 10.1126/science.abb2751.
Sept 10th - Diogo Santos (Taylor Lab)
Neuroendocrine mechanisms governing sex-differences in hyperalgesic priming involve prolactin receptor sensory neuron signaling
Paige C, Barba-Escobedo PA, Mecklenburg J, Patil M, Goffin V, Grattan DR, Dussor G, Akopian AN, Price TJ. J Neurosci. 2020 Aug 12;JN-RM-1499-20. doi: 10.1523/JNEUROSCI.1499-20.2020
Sept 17th - Kim Meerschaert (Davis Lab)
An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents
Prescott SL, Umans BD, Williams EK, Brust RD, Liberles SD. Cell 2020 Apr 30;181(3):574-589.e14. doi: 10.1016/j.cell.2020.03.004. Epub 2020 Apr 6. PMID: 32259485 PMCID: PMC7197391 (available on 2021-04-30) DOI: 10.1016/j.cell.2020.03.004
Sept 24th - Kelly Smith (Ross Lab)
Low-threshold mechanosensitive VGLUT3-lineage sensory neurons mediate spinal inhibition of itch by touch.
Sakai K, Sanders KM, Lin S-H, Pavlenko D, Funahashi H, Lozada T, Hao S, Chen C-C, Akiyama T. J Neurosci. 2020 Sep 7;JN-RM-0091-20. doi: 10.1523/JNEUROSCI.0091-20.2020. Online ahead of print.
Oct 1st - Jamie Moy (Gold Lab)
SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia
Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, Stratton HJ, Cai S, Luo S, Gonzalez KB, Miller SP, Patwardhan A, Ibrahim MM, Khanna R. bioRxiv preprint doi: https://doi.org/10.1101/2020.07.17.209288. this version posted September 14, 2020
Oct 8th - Yanmei Qi (Taylor Lab)
Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids
Zhang X-Y, Dou Y-N, Yuan L, Li Q, Zhu YJ, Wang M, Sun YG. Elife. 2020 Jun 10;9:e55289. doi: 10.7554/eLife.55289.
Oct 15th - Andrew Liu (Kaplan Lab)
Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain
Barragán-Iglesias P, Franco-Enzástiga Ú, Jeevakumar V, Shiers S, Wangzhou A, Granados-Soto V, Campbell ZT, Dussor G, Price TJ. J Neurosci. 2020 Apr 29;40(18):3517-3532. doi: 10.1523/JNEUROSCI.3055-19.2020.
Oct 22nd - Sam Noh (Seal Lab)
Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity
Kohro Y, Matsuda T, Yoshihara K, Kohno K, Koga K, Katsuragi R, Oka T, Tashima R, Muneta S, Yamane T, Okada S, Momokino K, Furusho A, Hamase K, Oti T, Sakamoto H, Hayashida K, Kobayashi R, Horii T, Hatada I, Tozaki-Saitoh H, Mikoshiba K, Taylor V, Inoue K, Tsuda M. Nat Neurosci. 2020 Oct 5. doi: 10.1038/s41593-020-00713-4. Online ahead of print..
Oct 29th - Benjamin Warner (Kinchington Lab)
Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents
Tiwari V, He S-Q, Huang Q, Liang L, Yang F, Chen Z, Tiwari V, Fujita W, Devi LA, Dong X, Guan Y, Raja SN. Pain 2020 Apr;161(4):842-855. doi: 10.1097/j.pain.0000000000001768.
Nov 5th - Chris Norris (Taylor Lab)
Histone methyltransferase G9a diminishes expression of cannabinoid CB 1 receptors in primary sensory neurons in neuropathic pain
Luo Y, Zhang J, Chen L, Chen S-R, Chen H, Zhang G, Pan H-L. J Biol Chem. 2020 Mar 13;295(11):3553-3562. doi: 10.1074/jbc.RA119.011053. Epub 2020 Feb 4.
Nov 12th - Ariel Epouhe (Albers Lab)
Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.
Perner C, Flayer CH, Zhu X, Aderhold PA, Dewan ZNA, Voisin T, Camire RB, Chow OA, Chiu IM, Sokol CL. Immunity. 2020 Oct 21:S1074-7613(20)30413-1. doi: 10.1016/j.immuni.2020.10.001. Online ahead of print.
Nov 19th - Joyce Kim (Gold Lab)
Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia.
Dong W, Jin SC, Allocco A, Zeng X, Sheth AH, Panchagnula S, Castonguay A, Lorenzo LÉ, Islam B, Brindle G, Bachand K, Hu J, Sularz A, Gaillard J, Choi J, Dunbar A, Nelson-Williams C, Kiziltug E, Furey CG, Conine S, Duy PQ, Kundishora AJ, Loring E, Li B, Lu Q, Zhou G, Liu W, Li X, Sierant MC, Mane S, Castaldi C, López-Giráldez F, Knight JR, Sekula RF Jr, Simard JM, Eskandar EN, Gottschalk C, Moliterno J, Günel M, Gerrard JL, Dib-Hajj S, Waxman SG, Barker FG 2nd, Alper SL, Chahine M, Haider S, De Koninck Y, Lifton RP, Kahle KT. iScience. 2020 Sep 11;23(10):101552. doi: 10.1016/j.isci.2020.101552. eCollection 2020 Oct 23.
Summer 2020 (COVID-19) Schedule
April 30, 2020 - Nicole Scheff
Loss of p53 drives neuron reprogramming in head and neck cancer
Amit M, Takahashi H, Dragomir MP, Lindemann A, Gleber-Netto FO, Pickering CR, Anfossi S, Osman AA, Cai Y, Wang R, Knutsen E, Shimizu M, Ivan C, Rao X, Wang J, Silverman DA, Tam S, Zhao M, Caulin C, Zinger A, Tasciotti E, Dougherty PM, El-Naggar A, Calin GA, Myers JN. Nature. 2020 Feb;578(7795):449-454. doi: 10.1038/s41586-020-1996-3.
May 7, 2020 - Special Seminar: Diego Bohorquez, PhD
“How the Gut Drives our Sugar Preferences”
May 14, 2020 - Paramita Basu (Tayler Lab)
Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels.
Zhou X, Ma T, Yang L, Peng S, Li L, Wang Z, Xiao Z, Zhang Q, Wang L, Huang Y, Chen M, Liang S, Zhang X, Liu JY, Liu Z. Nat Commun. 2020 May 8;11(1):2293. doi: 10.1038/s41467-020-16210-y.
May 21, 2020 - Emanuel Loeza Alcocer (Gold Lab)
Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache.
Bonnet C, Hao J, Osorio N, Donnet A, Penalba V, Ruel J, Delmas P. Nat Commun. 2019 Sep 18;10(1):4253. doi: 10.1038/s41467-019-12197-3.
May 28, 2020 - Tayler Sheahan (Ross Lab)
Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons
Sharif B, Ase AR, Ribeiro-da-Silva A, Séguéla P
Neuron. 2020 Apr 7;S0896-6273(20)30228-2. doi: 10.1016/j.neuron.2020.03.021.
Spring 2020
January 9th 2020 - Hailey Bulls
Self-Guided Online Cognitive Behavioral Strategies for Chemotherapy-Induced Peripheral Neuropathy: A Multicenter, Pilot, Randomized, Wait-List Controlled Trial
Knoerl R, Smith EML, Barton DL, Williams DA, Holden JE, Krauss JC, LaVasseur B. J Pain. 2018 Apr;19(4):382-394. doi: 10.1016/j.jpain.2017.11.009. Epub 2017 Dec 8.
January 16th, 2020 - G Sinha (Taylor lab)
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes
Mapplebeck JCS, Lorenzo LE, Lee KY, Gauthier C, Muley MM, De Koninck Y, Prescott SA, Salter MW. Cell Rep. 2019 Jul 16;28(3):590-596.e4. doi: 10.1016/j.celrep.2019.06.059.
January 23rd, 2020 - K Meerschaert (Davis lab)
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Cell. 2020 Jan 9;180(1):33-49.e22. doi: 10.1016/j.cell.2019.11.014.
January 30th, 2020 - S Puig (Mahajan lab)
Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2
Parekh, Puja K, Logan RW, Ketchesin KD, Becker-Krail D, Shelton MS, Hildebrand MA, Barko K, Huang YH, and McClung CA. The Journal of Neuroscience, vol. 39, no. 24, Aug. 2019, pp. 4657–4667., doi:10.1523/jneurosci.2233-18.2019.
February 6th, 2020 - J Moy (Gold lab)
Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells
Nickolls Alec R., Lee MM, Espinoza DF, Szczot M, et al. Open Access Cell Press, vol. 30, no. 3, Jan . 2020, pp. 932-946, doi.org/10.1016/j.celrep.2019.12.062
February 13th, 2020 - K Clark (Gold lab)
Dorsal Root Ganglion Macrophages Contribute to Both the Initiation and Persistence of Neuropathic Pain
Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI. Nat Commun. 2020 Jan 14;11(1):264. doi: 10.1038/s41467-019-13839-2.
February 20th, 2020 - R Holland (Ross lab)Sharma, Nikhil, et al.The
The emergence of transcriptional identity in somatosensory neurons.
Sharma N, Flaherty K, Lezgiyeva K, Wagner DE, Klein AM, Ginty DD. Nature. 2020 Jan;577(7790):392-398. doi: 10.1038/s41586-019-1900-1. Epub 2020 Jan 8. PMID: 31915380
February 27th, 2020 - C Warwick (Koerber/Ross lab)
Cancelled
March 5th, 2020 - J Gedeon (Gold lab)
Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic Clamp
Mis, Malgorzata A., et al. The Journal of Neuroscience, vol. 39, no. 3, 2018, pp. 382–392., doi:10.1523/jneurosci.2433-18.2018.
March 12th, 2020 - Spring Break (No Journal Club)
March 19th, 2020 - E Nguyen (Ross lab)
Cancelled - COVID19 preparations
March 26th, 2020 - C Warwick (Ross/Koerber lab)
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain
Beaulieu-Laroche L, Christin M, Donoghue A, Agosti F, Yousefpour N, Petitjean H, Davidova A, Stanton C, Khan U, Dietz C, Faure E, Fatima T, MacPherson A, Mouchbahani-Constance S, Bisson DG, Haglund L, Ouellet JA, Stone LS, Samson J, Smith MJ, Ask K, Ribeiro-da-Silva A, Blunck R, Poole K, Bourinet E, Sharif-Naeini R. Cell. 2020 Mar 5;180(5):956-967.
April 2nd, 2020 - H Bobnar (Kolber lab)
SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKIIα Deacetylation in Central Amygdala
Zhou C, Wu Y, Ding X, Shi N, Cai Y, Pan ZZ. J Neurosci. 2020 Mar 11;40(11):2332-2342. doi: 10.1523.
April 9th, 2020 - T Nelson (Taylor lab)
Synaptic Dynamics of the Feed-forward Inhibitory Circuitry Gating Mechanical Allodynia in Mice
Wang Q, Zhang X, He X, Du S, Jiang Z, Liu P, Qi L, Liang C, Gu N, Lu Y. Anesthesiology. 2020 Feb 19. doi: 10.1097/ALN.0000000000003194. [Epub ahead of print].
April 16th, 2020 - D Ferreira (Seal lab)
Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury
Renthal W, Tochitsky I, Yang L, Cheng Y-C, Li E, Kawaguchi R, Geschwind DH, Woolf CJ. https://doi.org/10.1101/838854doi: bioRxiv preprint.
April 23rd, 2020 - S Salavatian (Mahajan lab)
Spinal Cord Stimulation With "Conventional Clinical" and Higher Frequencies on Activity and Responses of Spinal Neurons to Noxious Stimuli: An Animal Study.
Li S, Farber JP, Linderoth B, Chen J, Foreman RD. Neuromodulation. 2018 Jul;21(5):440-447. doi: 10.1111/ner.12725
Fall 2019
Aug. 27th 2019 - Koerber
An ultrafast system for signaling mechanical pain in human skin
Nagi SS, Marshall AG, Makdani A, Jarocka E, Liljencrantz J, Ridderström M, Shaikh S, O'Neill F, Saade D, Donkervoort S, Foley AR, Minde J, Trulsson M, Cole J, Bönnemann CG, Chesler AT, Bushnell MC, McGlone F, Olausson H. Sci Adv, 2019. doi: 10.1126/sciadv.aaw1297.
Sept. 3rd 2019 - Dos Santos (Taylor Lab)
TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes
Fischer R, Sendetski M, Del Rivero T, Martinez GF, Bracchi-Ricard V, Swanson KA, Pruzinsky EK, Delguercio N, Rosalino MJ, Padutsch T, Kontermann RE, Pfizenmaier K, Bethea JR. PNAS, 2019. 116(34):17045-17050. doi: 10.1073/pnas.1902091116.
Sept. 10th 2019 - Noh (Seal Lab)
Specialized cutaneous Schwann cells initiate pain sensation
Abdo H, Calvo-Enrique L, Lopez JM, Song J, Zhang MD, Usoskin D, El Manira A, Adameyko I, Hjerling-Leffler J, Ernfors P. Science, 2019. 365(6454):695-699. doi: 10.1126/science.aax6452.
Sept. 17th 2019 - Salsovic (Koerber Lab)
Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons
Petitjean H, B Bourojeni F, Tsao D, Davidova A, Sotocinal SG, Mogil JS, Kania A, Sharif-Naeini R. Cell Rep., 2019 Aug 6;28(6):1429-1438.e4. doi: 10.1016/j.celrep.2019.07.048.
Sept. 24th 2019 - Pineda-Farias (Gold Lab)
A neuronal circuit for activating descending modulation of neuropathic pain
Huang J, Gadotti VM, Chen L, Souza IA, Huang S, Wang D, Ramakrishnan C, Deisseroth K, Zhang Z, Zamponi GW. Nat Neurosci. 2019 Oct;22(10):1659-1668. doi: 10.1038/s41593-019-0481-5.
Oct. 1st 2019 - Nelson(Taylor Lab)
Itch Webinar (moderated by Sarah Ross)
Oct. 8th 2019 - Epouhe (Lab)
Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity
Castro J, Harrington AM, Lieu T, Garcia-Caraballo S, Maddern J, Schober G, O'Donnell T, Grundy L, Lumsden AL, Miller PE, Ghetti A, Steinhoff MS, Poole DP, Dong X, Chang L, Bunnett NW, Brierley SM. JCI Insight. 2019 Sep 19. pii: 131712. doi: 10.1172/jci.insight.131712.
Oct. 15th 2019 - Nelson (Taylor Lab)
Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch
Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, Goulding M. Cell Rep. 2019 Jul 16;28(3):625-639.e6. doi: 10.1016/j.celrep.2019.06.033.
Oct. 22nd 2019 - SFN
Oct. 29th 2019 - Hartung (Gold Lab)
Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors
Zheng W, Nikolaev YA, Gracheva EO, Bagriantsev SN. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17547-17555. doi: 10.1073/pnas.1910213116.
Nov. 5th 2019 - Smith (Ross Lab)
How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch
Pagani M, Albisetti GW, Sivakumar N, Wildner H, Santello M, Johannssen HC, Zeilhofer HU. Neuron. 2019 Jul 3;103(1):102-117.e5. doi: 10.1016/j.neuron.2019.04.022.
Nov. 12th 2019 - Warwick (Ross/Koerber Lab)
Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements
Paixão S, Loschek L, Gaitanos L, Alcalà Morales P, Goulding M, Klein R. Neuron. 2019 Oct 2. pii: S0896-6273(19)30735-4. doi: 10.1016/j.neuron.2019.08.029.
Nov. 19th 2019 - Clark (Gold Lab)
TRESK K+ Channel Activity Regulates Trigeminal Nociception and Headache
Guo Z, Qiu CS, Jiang X, Zhang J, Li F, Liu Q, Dhaka A, Cao YQ. eNeuro. 2019 Jul 29;6(4). pii: ENEURO.0236-19.2019. doi: 10.1523/ENEURO.0236-19.2019. Print 2019 Jul/Aug.
Dec. 3rd 2019 - Ferriera (Lab)
Stereotyped transcriptomic transformation of somatosensory neurons in response to injury
Nguyen MQ, Le Pichon CE, Ryba N. Elife. 2019 Oct 8;8. pii: e49679. doi: 10.7554/eLife.49679.
Dec. 10th 2019 - Sheahan (Ross Lab)
Dual and Opposing Functions of the Central Amygdala in the Modulation of Pain
Wilson TD, Valdivia S, Khan A, Ahn HS, Adke AP, Martinez Gonzalez S, Sugimura YK, Carrasquillo Y. Cell Rep. 2019 Oct 8;29(2):332-346.e5. doi: 10.1016/j.celrep.2019.09.011.
Spring 2019
Jan. 8th 2019 - Tayler Sheahan (Ross Lab)
Identifying the pathways required for coping behaviors associated with sustained pain
Huang T., Lin S-H., Malewicz N.M., Zhang Y., Zhang Y., Goulding M., LaMotte R.H., Ma Q. Nature, 2018. doi.org/10.1038/s41586-018-0793-8.
Jan. 15th 2019 - Jamie Moy (Gold Lab)
The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence
Lee K., Vuong H.E., Nusbaum D.J., Hsiao E.Y., Evans C.J., Taylor A.M.W. Neuropsychopharmacology, 2018. 43:2606-2614.
Jan. 22nd 2019 - Isabella Fuentes (Taylor Lab)
Activation of the integrated stress response in nociceptors drives methylglyoxal-induced pain
Barragan-Iglesias P., Kuhn J., Vidal-Cantu G.C. Salinas-Abarca A.B., Granados-Soto V., Dussor G.O., Campbell Z.T., Price T.J. Pain, 2019. 160(1): 160-171.
Jan. 29th 2019 - Cynthia Arokiaraj (Seal Lab)
Merkel cells activate sensory neural pathways through adrenergic synapse
Hoffman B.U., Baba Y., Griffith T.N., Mosharov E.V., Woo S-H., Roybal D.D., Karsenty G., Patapoutian A., Sulzer D., Lumkin E.A. Neuron, 2018. 100: 1401-1413.
Feb. 5th 2019 - Sebastian Choi (Ginty Lab) *Special Research Presentation*
Feb. 12th 2019 - Kelly Smith(Ross Lab)
Tac1-expressing neurons in the periaqueductal gray facilitate the itch-scratching cycle via descending regulation
Gao Z-R., Chen W-Z., Liu M-Z., Chen X-J., Wan L., Zhang X-Y., Yuan L., Lin J-K., Wang M., Zhou L., Xu X-h., Sun Y-G. Neuron, 2018. 101: 45-59.
Feb. 19th 2019 - Sarah Najjar (Albers Lab)
Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction
Grundy L., Harrington A.M., Castro J., Garcia-Caraballo S., Deiteren A., Madden J., Rychkov G.Y., Ge P., Peters S., Feil R., Miller P., Ghetti A., Hannig G., Kurtz C.B., Silos-Santiago I., Brierley S.M . JCI Insight, 2018. 3(19):e121841..
Feb. 26th 2019 - Jeremy Gedeon (Dong Lab)
Mechanically activated piezo channels mediate touch and suppress acute mechanical pain response in mice
Zhang M., Wang Y., Geng J., Zhou S., Xiao B . Cell Reports, 2019. 26, 1419-1431.
March 5th 2019 - Michael Chiang (Ross Lab)
A mast-cell-specific receptor mediates neurogenic inflammation and pain
Green D.P., Limjunyawong N., Your N., Pundir P., Dong X . Neuron, 2019. 101,412-420.
March 12th 2019 - Spring Break
March 19th 2019 - Andy Cooper (Taylor Lab)
An amygdalae neural ensemble that codes the unpleasantness of pain
Corder G., Ahanonu B., Grewe B.F., Wang D., Schnitzer M.J., Scherrer G. Science, 2019. 363,276-281.
April 2nd 2019 - Spring Pain - APS Meetings
April 9th 2019 - Kim Meerschaert (Davis Lab)
5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-couple receptor D
Bautzova T., Hockley J.R.F., Perez-Berezo T., Pujo J., Tranter.M.M., Desormeaux C., Barbaro M.R., Basso L., LeFaouder P., Rolland C., Malapert P., Moqrich A., Eutamene H., Denadai-Souza A., Vergnolle N., St John Smith E., Hughes D.I., Barbara G., Dietrich G., Bulmer D.C., Cenac N. Sci. Signal, 2018. 11,eaal2171..
April 16th 2019 - Heather Allen (Kolber Lab)
A subpopulation of amygdala neurons mediates the affective component of itch
Sanders K.M., Sakai K., Henry T.D., Hashimoto T., Akiyama T. J Neurosci, 2019. 2759-18 (in press)..
April 23rd 2019 - Karen Clark (Gold Lab)
Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity
Akerman S., Karsan N., Bose P., Hoffman J.R., Holland P.R., Romero-Reyes M., Goadsby P.J. Brain, 2019. 142; 103-119.
Fall 2018
Aug. 28th 2018 - Brad Taylor
Functional divergence of delta and mu opioid receptor organization in CNS pain circuits
Wang W., Tawfik V.L., Corder G., Low S.A., Francois A., Basbaum A., Scherrer G. Neuron, 2018. 98:90-108.
Sept. 4th 2018 - Kristen Smith-Edwards (Davis lab)
A population of gut epithelial enterochromaffin cells is mechxnosensitive and requires Piezo2 to convert force into serotonin release
Alcaino C., Knutson K.R., Treichel A.J., Yildiz G., Strege P.R., Linden D.R., Li J.H., Leiter A.B., Szurszewski J.H., Farrugia G., Beyder A. PNAS, 2018. 115(32):E7632-E7641.
Sept. 18th 2018 - Cynthia Arokiaraj (Seal lab)
A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
Ding H., Kiguchi N., Yasuda D., Daga P.R., Polgar W.E., Lu J.J., Czoty P.W., Kishoka S., Zaverei N.T., Ko M-C. Sci. Transl. Med., 2018. 10(456) eaar3483.
Sept. 25th 2018 - Sarah Najjar (Albers lab)
Single-cell RNAseq reveals seven classes of colonic sensory neuron
Hockley J.R.F., Taylor T.S., Callejo G., Wilbrey A.L., Gutteridge A., Bach K., Winchester W.J., Bulmer D.C., McMurray G., St John Smith E. Gut Epub ahead of print 2018.0:1-12.
Oct. 2nd 2018 - Emanuel Loeza (Gold lab)
GABAa receptor subtypes regulates stress-induced colon inflammation in mice
Seifi M., Rodaway S., Rudolph U., Swinny J.D. Gastroenterology 2018. 155(3):852-864.
Oct. 9th 2018 - Kelly Smith (Ross lab)
Touch and tactile neuropathic pain sensitivity are set by corticospinal projections
Liu Y., Latremoliere A., Li X., Zhang Z., Chen M., Wang X., Fang C., Zhu J., Alexandre C., Gao Z., Chen B., Ding X., Zhou J-Y., Zhang Y., Chen C., Wang K.H., Woolf C.J.,m He Z. Nature 2018. 561: S47-S50.
Oct. 16th 2018 - Karen Clark (Gold lab)
Macrophage angiotensin II type 2 receptor triggers neuropathic pain
Shepherd A.J., Mickle A.D., Golden J.P., Mack M.R., Halabi C.M., de Kloet A.D., Samineni V.K., Kim B.S., Krause E.G., Gereau R.W., Mohaptra D.P. PNAS 2018. 115 (34): E805-E8066.
Oct. 30th 2018 - Tyler Nelson (Taylor lab)
NMDA receptor activation underlies the loss of spinal dorsal horn neurons and the transition to persistent pain after peripheral nerve injury
Inquimbert P., Moll M., Latremoliere A., Tong C-K., Zhang J., Sheehan G.F., Smith B.M., Korb E., Athie M.C.P., Babaniyi O., Ghasemlou N., Yanagawa Y., Allis C.D., Hof P.R., Scholtz J . Cell Reports 2018. 23: 2678-2689.
Nov. 13th 2018 - Joe Salsovic (Koerber lab)
Optogenetic activation of non-nociceptive Ab fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats
Tashima R., Koga K., Sekine M., Kanehisa K., Kohro Y., Tominaga K., Matsushita K., Tozaki-Saitoh H., Fukazawa Y., Inoue K., Yaw H., Furue H., Tsuda M. eNeuro 2018. 5(1): 1-14.
Nov. 27th 2018 - Charles Warwick (Koerber/Ross lab)
PIEZO2 mediates injury-induced tactile pain in mice and humans
Szczot M., Liljencrantz J., Ghitani N., Barik A., Lam R., Thompson J.H., Bharucha-Goebel D., Saade D., Necaise A., Donkervoort S., Foley A.R,, Gordon T., Case L., Bushnell M.C., Bonnemann C.G., Chesler A.T. Sci. Transl. Med. 2018. 10 October.
Dec. 4th 2018 - Kim Meerschaert (Davis lab)
A gut-brain neural circuit for nutrient sensory transduction
Kaelberer M.M., Buchanan K.L., Klein M.E., Barth B.B., Montoya M.M., Shen X., Bohorquez D.V. Science. 2018. 361, eaat5236.
Dec. 11th 2017 - Eileen Nguyen (Ross lab)
A brainstem-spinal circuit controlling nocifensive behavior
Barik A., Thompson J.H., Seltzer M., Ghitani N., Chesler A.T. Neuron. 2018. 100: 1-13.
Spring 2018
Jan. 9th 2018 - Brian Davis
Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing
Nguyen M.Q., Wu Y., Bonilla, L.S., von Buchholtz L.J., Ryba N.J.P. PLoS ONE, 2017. 12(9): 1-22.
Jan. 16th 2018 - Jane Hartung (Gold Lab)
A craniofacial-specific monosynaptic circuit enables heightened affective pain
Rodriguez E., Sakurai K., Xu J., Chen Y., Toda K., Zhao S., Han B-X., Ryu D., Yin H., Liedtke W., Wang F. Nature Neurosci., 2017. 20: 1734-1743.
Jan. 23rd 2018 - CANCELLED (Department of Neurobiology Seminar)
Jan. 30th 2018 - Michael Chiang (Ross Lab)
Keratinocytes mediate innocuous and noxious toch via ATP-P2X4 signalling
Moehring F., Cowie A.M., Menzel A.D. Weyer A.D., Grzybowski M., Arzua T., Geurts A.M., Polygin O., Stuck C.L. eLife, 2018. 7:e31684.
Feb. 6th 2018 - Lillian Laemmle (Kinchington Lab)
Over expression of u-opioid receptors in peripheral afferents, but not in combination with enkephalin, decreases neuropathic pain behavior and enhances opined analgesia in mice
Klein A.H., Mohammad H.K., Ali R., Peper B., Wilson S.P., Raja S.N., Ringkamp M., Schweitzer S. Anesthesiology - Pain Medicine , 2018. epub.
Feb. 13th 2018 - Brian Edwards (Davis Lab)
Microbiota regulates visceral pain in the mouse
Luczynski P., Tramullas M., Viola M., Shanahan F., Clarke G., O'Mahony S., Dinan T.G., Cryan JF. eLife, 2017;6:e25887.
Feb. 20th 2018 - Joe Salsovic (Koerber Lab)
Functional and molecular characterization of mechanoinsensitive "silent" nociceptors
Prato V., Taberner F.J., Hockley J.R.F., Callejo G., Arcourt A., Tazir B., Hammer L., Schad P., Heppenstall P.A., Smith E.S., Lechner S.G. Cell Reports, 2017; 21, 3102-3115.
Feb. 27th 2018 - Sarah Najjar (Albers Lab)
Protease-mediated suppression of DRG neuron excitability by commensal bacteria
Sessenwein J.L., Baker C.C., Pradhananga S., Maitland M.E., Petrof E.O., Allen-Varcoe E., Noordhof C., Reed D.E., Vanner S.J., Lomax A.E. J Neurosci, 2017; 37(48): 11758-11768.
March 6th 2018 - Spring Break
March 13th 2018 - Jillian Weeks (Sved Lab)
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer
Watanabe M., Narita M., Hamada Y., Yamashita A., Tamura H., Ikegami D., Kondo T., Shinzato T., Shimizu T., Fukuchi Y., Muto A., Okano H., Yamanaka A., Tawfik V.L., Kuzumaki N., Navratilova E., Porreca F., Narita M. Molecular Pain, 2018; 14: 1-11.
March 20th 2018 - Cynthia Arokiaraj (Seal Lab)
Massively parallel single nucleus transcriptional profiling defines spinal cord neurons and their activity during behavior
Sathyamurthy A., Johnson K.R., Matson K.J.E., Dobrott C.I., Li L., Ryba A.R., Bergman T.B., Kelly M.C., Kelley M.W., Levine A.J. Cell Reports, 2018; 22: 2216-2225.
March 27th 2018 - Kim Meerschaert (Davis Lab)
Nociceptor sensory neurons suppress neutrophil and gamma/delta T cell responses in bacterial lung infections and lethal pneumonia
Barrel P., Umans B.D., Li L., Wallrapp A., Bist M., Kirschbaum T., Wei Y., Zhou Y., Kuchroo V.K., Burkett P.R., Yipp B.G., Liberles S.D., Chiu I.M. Nature Medicine, 2018; published online March 5.
April 3rd 2018 -Andy Cooper (Taylor Lab)
A neural circuit for the suppression of pain by a competing need state
Alhadeff A.L., Su Z., Hernandez E., Klima M.L., Phillips S.Z., Holland R.A., Gut C., Hantman A.W., De Jonghe B.C., Bentley J.N. Cell, 2018; 173, 140-152.
April 10th 2018 - David Ferreira (Seal Lab)
Mechanistic differences in neuropathic pain modalities revealed by correlating behavior with global expression profiling
Cobos EJ., Nickerson C.A., Gao F., Chandra V., Bravo-Caparros I., ....., Rangachari M., Woolf C.J., Costigan M. Cell Reports, 2018; 22, 1301-1312.
April 17th 2018 - Tayler Sheahan (Ross Lab)
Circuit dissection of the role of somatostatin in itch and pain
Huang J., Polar E., Solinski H. J., Mishra S.K., ......, Zeilhofer H.U., Watanabe M., Riddell J.S., Todd A.J., Hoon, M.A. Nature Neurosci., 2018; (Epub ahead of print)
April 24th 2018 - Jamie Moy (Gold Lab)
DRG voltage-gated sodium channel 1.7 is upregulated in paclitaxel-induced neuropathy in rats and humans with neuropathic pain
Li Y., North R.Y., Rhines L.D., Esteves Tatsui C., Rao G., Edwards D.D., Cassidy R.M., Harrison D.S., Johansson C.A., Zhang H. Dougherty P.M. J Neurosci., 2018; 38(5):1124-1136.
Fall 2017
Aug. 29th 2017 - Sarah Ross
Specialized mechanosensory nociceptors mediating rapid response to hair pull
Ghitani N, Barik A, Szczot M, Thompson JH, Li C, Le Pichon CE, Krashes, MJ and Chesler, AT. Neuron, 2017. 95: p. 944-54.
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Sept. 5th 2017 - Jane Hartung (Gold lab)
Epiregulin and EGFR interactions are involved in pain processing
Martin, L. J., S. B. Smith, A. Khoutorsky, C. A. Magnussen, A. Samoshkin, R. E. Sorge, C. Cho, N. Yosefpour, S. Sivaselvachandran, S. Tohyama, T. Cole, T. M. Khuong, E. Mir, D. G. Gibson, J. S. Wieskopf, S. G. Sotocinal, J. S. Austin, C. B. Meloto, J. H. Gitt, C. Gkogkas, N. Sonenberg, J. D. Greenspan, R. B. Fillingim, R. Ohrbach, G. D. Slade, C. Knott, R. Dubner, A. G. Nackley, A. Ribeiro-da-Silva, G. G. Neely, W. Maixner, D. V. Zaykin, J. S. Mogil and L. Diatchenko. Journal of Clinical Investigation, 2017. in press.
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Sept. 12th 2017 - Colleen Cassidy (Koerber lab)
Distinct behavioral responses evoked by selective optogenetic stimulation of major TRPV1+ and MrgD+ subsets of C-fibers
Beady H., Daou I., Ase A.R., Ribeiro-de-Silva A., Seguela P. Pain, 2017. in press.
Sept. 19th 2017 - Cancelled
Sept. 26th 2017 - Jami Saloman (Davis lab)
Gut microbiota is critical for the induction of chemotherapy-induced pain
Shen S., Lim G., You Z., Ding W., Huang P., Ran C., Doheny J., Caravan P., Tate S., Hu K., Kim H., McCabe M., Huang B., Xie Z., Kwon D., Chen L.,Mao J. Nature Neurosci, 2017. 20 (9): 2013-18.
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Oct. 3rd 2017 - Sarah Najjar (Albers lab)
Enterochromaffin cells are gut chemosensory that couple to sensory neural pathways
Bellano N.W., Bayrer J.R., Leitch D.B., Castro J., Zhang C., O'Donnell T.A., Brierley S.M., Ingraham H.A, Julius D. Cell, 2017. 170: 185-198.
Oct. 10th 2017 - Cynthia Arokiaraj (Seal lab)
A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity
Tan L.L., Pelter P., Heinl C., Tang W., Gangadharan V., Flor H., Sprengel R., Kuner T., Kuner R. Nature Neurosci., 2017. Advanced online publication.
Oct. 17th 2017 - Jorge Pineda (Gold lab)
miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
Peng C., Li L., Zhang M.D., Gonzales C.B., Parisien M., Belfer I., Usoskin D., Abdo H., Furlan A., Haring M., Lallemand F., Harkany T., Diatchenko L., Hokfelt T., Hjerling-Leffler J., Ernfors P. Science, 2017, 356: 1168-1171.
Oct. 24th 2017 - Stephanie Puig (Gutstein lab)
Site-specific regulation of P2X7 receptor function in microglia gates morphine analgesic tolerance
Leduc-Pessah H., Weilinger N.L., Fan C.Y., Burma N.E., Thompson R.J., Trang T. J Neurosci, 2017, Advanced online publication.
Oct. 31st 2017 - Joe Salsovic (Koerber lab)
Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source
Weir G.A., Middleton S.J., Clark A.J., Daniel, T., Khovanov N., McMahon S.B., Bennett D.L. Brain, 2017: 140, 2570-2585.
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Nov. 7th 2017 - Kristen Smith Edwards (Davis lab)
Ex vivo study of human visceral nociceptors
McGuire C., Boundouki G., Hockley J.R.F., Reed D., Cibert-Goton V., Peiris M., Kung V., Broad J., Aziz Q., Chan C., Ahmed S., Thaha M.A., Sanger G.J., Blackshaw L.A., Knowles C.H., Bulmer D.C. Gut, 2016; 0:1-11
Nov. 14th 2017 - SFN week
Nov. 21st 2017 - Thanksgiving break
Nov. 28th 2017 - Emanuel Loeza (Gold lab)
α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors
Castro J., Harrington A.M., Garcia-Caraballo S., Maddem J., Grundy L., Zhang J., Page G., Miller P.E., Craik D.J., Adams D.J., Brierley S.M. Gut, 2017;66:1083-1094.
Dec. 5th 2017 - Jillian Weeks (Sved lab)
Nicotinic modulation of descending pain control circuitry
Umana I.C., Daniele C.A., Miller B.A., Abburi C., Gallagher K., Brown M.A., Mason P., McGehee D.S. Pain, 2017; 158:1938-1950.
Dec. 12th 2017 - Junichi Hachisuka (Ross lab)
A central neural circuit for itch sensation
Mu D., Deng J., Ke-Fei L., Wu Z-Y., Shi Y-F., Guo W-M., Mao Q-Q., Liu X-J., Li H., Sun Y-G. Science, 2017; 357:695-699.
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Spring 2017
Jan. 3rd 2017 - John Horn
Espinosa-Medina I, Saha O, Boismoreau F, Chettouh Z, Rossi F, Richardson WD and Brunet JF. Science, 2016. 354(6314): p. 893 - 7.
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consensus: developmental biologists and physiologists come head-to-head!
discussion from this journal club led to an eLetter response in Science.
Jan. 10th 2017 - Cedric Peirs (Seal lab)
Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA and Lechner SG. Neuron, 2016. in press
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consensus: very cool paper and outstanding presentation. double kudos!
Jan. 17th 2017 - Qing Liu
Bikoff J, Gabito MI, Rivard AF, Drobac E, Machado TA, Miri A, Brenner-Morton S, Famojure E, Diaz C, Alvarez FJ, Mentis GZ, and Jessel TM. Cell, 2016. 165(1) 207-219
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consensus: so many subtypes!
Jan. 24th 2017 - Keith Vogt
Brasher AK, Becker S, Hoeppli ME, Schweinhardt P. J Neurosci, 2016. 38(18):5013-5020
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consensus: this is an important question
Jan. 31st 2017 - Stephanie Puig (Gutstein Lab)
Corder G, Tawfik VL, Sypek EI, Low SA, Dickinson JR,Sotoudeh C, Clark JD, Barres, BA, Bohlen CJ, and Scherrer G. Nat Medicine, 2017.published online Jan. 16.
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consensus: so interesting -- lots of discussion!
Feb. 7th 2017 - Emanuel Loeza (Gold lab)
Nam Y, Kim J-H, Kim J-H, Jha MK, Jung JY, Lee M-G, Choi I-S, Jang I-S, Lim DG, Hwang S-H, Cho H-J, Suk K. Cell Reports, 2016. 17, 3049-3061
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consensus: nice job Emanuel!
Feb. 14th 2017 - Tara Deemyad (Urban lab)**
Han Q, Kin YH, Wang X, Liu D, Zhang Z-J, Bey AL, Lay M, Chang W, Berta T, Zhang Y, Jiang Y-H, Ji RR. Neuron, 2016. 92, 1279-1293
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consensus: novel presynaptic function for Shank!
Feb. 21st 2017 - Lindsey Snyder (Ross lab)
Francois A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Ritola KD, Shariff-Naeini R, Deiseroth K, Delp SL,Malenka RC, Juo,L, Hantman AW, and Scherrer G. Neuron, 2017. 93, 1-18
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consensus: Tour de force highlighting cool viral experiments
Feb. 28th 2017 - Jane Hartung (Gold lab)
Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Mousseau M, Shankar JV, Stemkowski PL, Baimoukhametova D, Bains JS, Antle MC, Zamponi GW, Cahill CM, Borgland SL, De Koninck Y, Trang T. Nat Medicine, 2017. Jan 30 [Epub ahead of print]
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consensus: Intriguing results sparked a heated debate over the presence of opioid receptors in glial cells.
March 7th 2017 - Spring Break
March 14th 2017 - Michael Chiang (Ross lab)**
Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Neuron, 2017. 93, 840-853.
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consensus: this was the most hilarious journal club ever.
March 21st 2017 - Sarah Najjar (Albers lab)
Ibrahim MM, Patwardhan A, Galbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Pain, 2017. 158 (2), 347-360.
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consensus: wow! this is very intriguing, and a huge caution for all of us doing real time place aversion with light.
March 28th 2017 - Jami Soloman (Davis lab)
Sinha S, Fu Y, Grimont A, Ketcham, M, Lafaro K, Saglimbeni JA, Askan G, Bailey JM, Melchior JP, Zhong Y, Joo MG, Grbovic-Huezo O, Yang IH, Basturn O, Baker L, Park Y, Kurtz RC, Tuveston D, Leach SD and Pasricha PJ. Cancer Research 2017. in press.
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consensus: cool insight into the mystery of neural-epithelial crosstalk in cancer — substance P!
April 4th 2017 - Colleen Cassidy (Koerber lab)
Wetzel C, Pilfer S, Picci C, Gok C, Hoffman D,Bali KK, Lampe A,Lapatsina L, Fleischer R, St John Smith E, Begay V, Moroni M, Estebanez L, Kuhnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Tuner R, Poulet JFA, Schmoranger J, Poole K and Lewin G. Nature Neuroscience 2017. 20(2), 209-218.
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April 11th 2017 - Junichi Hachisuka (Ross lab)
Yu YQ, Barry DM, Hao Y, Liu XT, Chen ZF. Science 2017. 355, 1072-1076.
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consensus: the optogenetic data are pretty compelling -- who would of guessed that the SCN is involved in itch?
April 18th 2017 - Distinguished Speaker Lunch
April 25th 2017 - Cynthia Arokiaraj (Seal lab)
Du X,Hao H,Yang Y, Huang, S, Wang C, Gigot S, Ramli R, Li X, Jaworski E, Edwards I, Deuchars J, Yanagawa Y, QI J, Guan B, Jaffe DB, Zhang H, Gamper N. J Clin Invest 2017. April 4. [Epub ahead of print].
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Fall 2016
Aug. 30th 2017 - Maggie Wright (Koerber lab)
Osteen, J.D., V. Herzig, J. Gilchrist, J.J. Emrick, C. Zhang, X. Wang, J. Castro, S. Garcia-Caraballo, L. Grundy, G.Y. Rychkov, A.D. Weyer, Z. Dekan, E.A.B. Undheim, P. Alewood, C.L. Stucky, S.M. Brierley, A.I. Basbaum, F. Bosmans, G.F. King, and D. Julius. Nature, 2016. 534(7608): p. 494-499.
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consensus: watch out for those spiders - fantastic presentation Maggie of a very interesting paper!
Sept. 6th 2016 - Jami Saloman (Davis lab)
Xie, W., S. Chen, J. A. Strong, A. L. Li, I. P. Lewkowich and J. M. Zhang The Journal of neuroscience 2016.36(33): 8712-8725.
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consensus: microsympa-wow! tricky surgery. very impressive!
Sept. 13th 2016 - Michael Chiang (Ross lab)
Ran C, Hoon MA, Chen X Nat Neurosci. 2016 Sep; 19(9):1201-9.
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consensus: such an exciting proof of concept -- this is the future of understanding spinal microcircuits
Sept. 20th 2016 - Matt Rannals (Urban lab)**
Maza C, Lepousez, G, Nissant A, Valley MT and Lledo PM, Nat Neurosci. 2016 Aug; 36(32):8289-8304.
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consensus: nice job Matt, teasing apart the function of a particular synapse in top-down control!
Sept. 27th 2016 - Sarah Najjar (Albers lab)
Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spray DC, Dong X. Neuron, 2016. 91(5): p. 1085-96.
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consensus: excitatory communication between neurons generated excited communication among scientists.
Sarah, your journal club generated an outstanding discussion!
Oct. 4th 2016 - Cedric Peirs (Seal lab)
Cui L, Miao X, Liang L, Abdus-Saboor I, Olson W, Flemming MS, Ma M, Tao Y, Luo W. Neuron, 2016. 91(5): p. 1137-53.
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consensus: these are some really powerful inhibitory interneurons!
Oct. 11th 2016 - Jorge Pineda (Gold lab)
Tan CH and Mcnaughton PA. Nature, 2016. 460(536).
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consensus: we are feeling warm all over -- cool new heat transducer
Oct. 18th 2016 - Stephanie Puig (Gutstein lab)
Brackley, AD, Gomez, R, Akopian AN, Henry MA and Jeske NA. Cell Report, 2016. 16(2686).
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consensus: location, location, location!
Oct. 25th 2016 - Colleen Cassidy (Koerber lab)
Chang W, Kanda H, Ikeda, R, Ling J, De Berry, JJ, Gu JG PNAS, 2016. 113(37) E5491.
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consensus: I like the feel of this!
Nov. 1st 2016 - Lindsey Snyder (Ross lab) **
Wiltschko AB, Johnson MG, Iurilli G, Peterson ER, Katon JS, Pashkovski SL, Abraira VE, Adams RP and Datta SR Neuron, 2015. 88(1121).
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consensus: Great Journal Club! Can't wait to see improvements enabling the
behaviors
Nov. 8th 2016 - Melissa Giraldo Duque (Gold lab)
Smith ML, Hostetler CM, Heinricher MM, Ryabinin AE Science Advances, 2016. 2(10):e1600855.
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consensus: sensitive creatures!
Nov. 15th 2016 - SfN week
Nov. 22nd 2016 - Thanksgiving week
Nov. 29th 2016 - Marissa Kuzirian (Ross lab)
Sakurai K, Zhao S, Takatoh J, Rodriguez E, Lu J, Leavitt AD, Fu M, Han BX and Wang F Neuron, 2016. 92(1).
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consensus: this paper was outstanding! What an awesome new tool!
Dec. 6th 2016 - Junichi Hachisuka (Ross lab)
Christensen AJ, Iyer SM, Francois A, Vyas S, Ramakrishnan C, Vesuna S, Deisseroth K, Scherrer G and Delp SL Cell Reports, 2016. 17(6)1699.
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consensus: we're lighting up with excitement over this one!
Dec. 13th 2016 - Jane Hartung (Gold lab)
Emery EC, Liuz, AP, Sikander S, Magnusdottir R, Dong X, Wood JN Science Advances, 2016. 2:e1600990.
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consensus: surprisingly controversial. Wow!
discussion from this journal club led to a heated debate