Stay current with advances in the field of pain research! The Pain Journal Club meets weekly during the fall and spring semesters to discuss cutting edge papers about pain, from mechanisms to circuitry. Presentations are made by Pain Center trainees (graduate student and postdocs) but the emphasis is on interactive discussions. All are welcome to attend. Students are welcome to take this as a one-credit class (MSNBIO 2651). Meetings are Tuesdays at noon in BST 1495. For more information, contact Rick Koerber (rkoerber@pitt.edu).
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Journal Club Schedule Fall 2018
Aug. 28th 2018 - Brad Taylor
Functional divergence of delta and mu opioid receptor organization in CNS pain circuits
Wang W., Tawfik V.L., Corder G., Low S.A., Francois A., Basbaum A., Scherrer G. Neuron, 2018. 98:90-108.
Sept. 4th 2018 - Kristen Smith-Edwards (Davis lab)
A population of gut epithelial enterochromaffin cells is mechxnosensitive and requires Piezo2 to convert force into serotonin release
Alcaino C., Knutson K.R., Treichel A.J., Yildiz G., Strege P.R., Linden D.R., Li J.H., Leiter A.B., Szurszewski J.H., Farrugia G., Beyder A. PNAS, 2018. 115(32):E7632-E7641.
Sept. 18th 2018 - Cynthia Arokiaraj (Seal lab)
A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
Ding H., Kiguchi N., Yasuda D., Daga P.R., Polgar W.E., Lu J.J., Czoty P.W., Kishoka S., Zaverei N.T., Ko M-C. Sci. Transl. Med., 2018. 10(456) eaar3483.
Sept. 25th 2018 - Sarah Najjar (Albers lab)
Single-cell RNAseq reveals seven classes of colonic sensory neuron
Hockley J.R.F., Taylor T.S., Callejo G., Wilbrey A.L., Gutteridge A., Bach K., Winchester W.J., Bulmer D.C., McMurray G., St John Smith E. Gut Epub ahead of print 2018.0:1-12.
Oct. 2nd 2018 - Emanuel Loeza (Gold lab)
Oct. 9th 2018 - Kelly Smith (Ross lab)
Oct. 16th 2018 - Karen Clark (Gold lab)
Oct. 30th 2018 - Tyler Nelson (Taylor lab)
Nov. 13th 2018 - Joe Salsovic (Koerber lab)
Nov. 27th 2018 - Charles Warwick (Koerber/Ross lab)
Dec. 4th 2018 - Kim Meerschaert (Davis lab)
Dec. 11th 2017 - Eileen Nguyen (Ross lab)
Previous Journal Club Schedule Spring 2018
Jan. 9th 2018 - Brian Davis
Diversity amongst trigeminal neurons revealed by high throughput single cell sequencing
Nguyen M.Q., Wu Y., Bonilla, L.S., von Buchholtz L.J., Ryba N.J.P. PLoS ONE, 2017. 12(9): 1-22.
Jan. 16th 2018 - Jane Hartung (Gold Lab)
A craniofacial-specific monosynaptic circuit enables heightened affective pain
Rodriguez E., Sakurai K., Xu J., Chen Y., Toda K., Zhao S., Han B-X., Ryu D., Yin H., Liedtke W., Wang F. Nature Neurosci., 2017. 20: 1734-1743.
Jan. 23rd 2018 - CANCELLED (Department of Neurobiology Seminar)
Jan. 30th 2018 - Michael Chiang (Ross Lab)
Keratinocytes mediate innocuous and noxious toch via ATP-P2X4 signalling
Moehring F., Cowie A.M., Menzel A.D. Weyer A.D., Grzybowski M., Arzua T., Geurts A.M., Polygin O., Stuck C.L. eLife, 2018. 7:e31684.
Feb. 6th 2018 - Lillian Laemmle (Kinchington Lab)
Over expression of u-opioid receptors in peripheral afferents, but not in combination with enkephalin, decreases neuropathic pain behavior and enhances opined analgesia in mice
Klein A.H., Mohammad H.K., Ali R., Peper B., Wilson S.P., Raja S.N., Ringkamp M., Schweitzer S. Anesthesiology - Pain Medicine , 2018. epub.
Feb. 13th 2018 - Brian Edwards (Davis Lab)
Microbiota regulates visceral pain in the mouse
Luczynski P., Tramullas M., Viola M., Shanahan F., Clarke G., O'Mahony S., Dinan T.G., Cryan JF. eLife, 2017;6:e25887.
Feb. 20th 2018 - Joe Salsovic (Koerber Lab)
Functional and molecular characterization of mechanoinsensitive "silent" nociceptors
Prato V., Taberner F.J., Hockley J.R.F., Callejo G., Arcourt A., Tazir B., Hammer L., Schad P., Heppenstall P.A., Smith E.S., Lechner S.G. Cell Reports, 2017; 21, 3102-3115.
Feb. 27th 2018 - Sarah Najjar (Albers Lab)
Protease-mediated suppression of DRG neuron excitability by commensal bacteria
Sessenwein J.L., Baker C.C., Pradhananga S., Maitland M.E., Petrof E.O., Allen-Varcoe E., Noordhof C., Reed D.E., Vanner S.J., Lomax A.E. J Neurosci, 2017; 37(48): 11758-11768.
March 6th 2018 - Spring Break
March 13th 2018 - Jillian Weeks (Sved Lab)
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer
Watanabe M., Narita M., Hamada Y., Yamashita A., Tamura H., Ikegami D., Kondo T., Shinzato T., Shimizu T., Fukuchi Y., Muto A., Okano H., Yamanaka A., Tawfik V.L., Kuzumaki N., Navratilova E., Porreca F., Narita M. Molecular Pain, 2018; 14: 1-11.
March 20th 2018 - Cynthia Arokiaraj (Seal Lab)
Massively parallel single nucleus transcriptional profiling defines spinal cord neurons and their activity during behavior
Sathyamurthy A., Johnson K.R., Matson K.J.E., Dobrott C.I., Li L., Ryba A.R., Bergman T.B., Kelly M.C., Kelley M.W., Levine A.J. Cell Reports, 2018; 22: 2216-2225.
March 27th 2018 - Kim Meerschaert (Davis Lab)
Nociceptor sensory neurons suppress neutrophil and gamma/delta T cell responses in bacterial lung infections and lethal pneumonia
Barrel P., Umans B.D., Li L., Wallrapp A., Bist M., Kirschbaum T., Wei Y., Zhou Y., Kuchroo V.K., Burkett P.R., Yipp B.G., Liberles S.D., Chiu I.M. Nature Medicine, 2018; published online March 5.
April 3rd 2018 -Andy Cooper (Taylor Lab)
A neural circuit for the suppression of pain by a competing need state
Alhadeff A.L., Su Z., Hernandez E., Klima M.L., Phillips S.Z., Holland R.A., Gut C., Hantman A.W., De Jonghe B.C., Bentley J.N. Cell, 2018; 173, 140-152.
April 10th 2018 - David Ferreira (Seal Lab)
Mechanistic differences in neuropathic pain modalities revealed by correlating behavior with global expression profiling
Cobos EJ., Nickerson C.A., Gao F., Chandra V., Bravo-Caparros I., ....., Rangachari M., Woolf C.J., Costigan M. Cell Reports, 2018; 22, 1301-1312.
April 17th 2018 - Tayler Sheahan (Ross Lab)
Circuit dissection of the role of somatostatin in itch and pain
Huang J., Polar E., Solinski H. J., Mishra S.K., ......, Zeilhofer H.U., Watanabe M., Riddell J.S., Todd A.J., Hoon, M.A. Nature Neurosci., 2018; (Epub ahead of print)
April 24th 2018 - Jamie Moy (Gold Lab)
DRG voltage-gated sodium channel 1.7 is upregulated in paclitaxel-induced neuropathy in rats and humans with neuropathic pain
Li Y., North R.Y., Rhines L.D., Esteves Tatsui C., Rao G., Edwards D.D., Cassidy R.M., Harrison D.S., Johansson C.A., Zhang H. Dougherty P.M. J Neurosci., 2018; 38(5):1124-1136.
Previous Journal Club Schedule Fall 2017
Aug. 29th 2017 - Sarah Ross
Specialized mechanosensory nociceptors mediating rapid response to hair pull
Ghitani N, Barik A, Szczot M, Thompson JH, Li C, Le Pichon CE, Krashes, MJ and Chesler, AT. Neuron, 2017. 95: p. 944-54.
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Sept. 5th 2017 - Jane Hartung (Gold lab)
Epiregulin and EGFR interactions are involved in pain processing
Martin, L. J., S. B. Smith, A. Khoutorsky, C. A. Magnussen, A. Samoshkin, R. E. Sorge, C. Cho, N. Yosefpour, S. Sivaselvachandran, S. Tohyama, T. Cole, T. M. Khuong, E. Mir, D. G. Gibson, J. S. Wieskopf, S. G. Sotocinal, J. S. Austin, C. B. Meloto, J. H. Gitt, C. Gkogkas, N. Sonenberg, J. D. Greenspan, R. B. Fillingim, R. Ohrbach, G. D. Slade, C. Knott, R. Dubner, A. G. Nackley, A. Ribeiro-da-Silva, G. G. Neely, W. Maixner, D. V. Zaykin, J. S. Mogil and L. Diatchenko. Journal of Clinical Investigation, 2017. in press.
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Sept. 12th 2017 - Colleen Cassidy (Koerber lab)
Distinct behavioral responses evoked by selective optogenetic stimulation of major TRPV1+ and MrgD+ subsets of C-fibers
Beady H., Daou I., Ase A.R., Ribeiro-de-Silva A., Seguela P. Pain, 2017. in press.
Sept. 19th 2017 - Cancelled
Sept. 26th 2017 - Jami Saloman (Davis lab)
Gut microbiota is critical for the induction of chemotherapy-induced pain
Shen S., Lim G., You Z., Ding W., Huang P., Ran C., Doheny J., Caravan P., Tate S., Hu K., Kim H., McCabe M., Huang B., Xie Z., Kwon D., Chen L.,Mao J. Nature Neurosci, 2017. 20 (9): 2013-18.
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Oct. 3rd 2017 - Sarah Najjar (Albers lab)
Enterochromaffin cells are gut chemosensory that couple to sensory neural pathways
Bellano N.W., Bayrer J.R., Leitch D.B., Castro J., Zhang C., O'Donnell T.A., Brierley S.M., Ingraham H.A, Julius D. Cell, 2017. 170: 185-198.
Oct. 10th 2017 - Cynthia Arokiaraj (Seal lab)
A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity
Tan L.L., Pelter P., Heinl C., Tang W., Gangadharan V., Flor H., Sprengel R., Kuner T., Kuner R. Nature Neurosci., 2017. Advanced online publication.
Oct. 17th 2017 - Jorge Pineda (Gold lab)
miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
Peng C., Li L., Zhang M.D., Gonzales C.B., Parisien M., Belfer I., Usoskin D., Abdo H., Furlan A., Haring M., Lallemand F., Harkany T., Diatchenko L., Hokfelt T., Hjerling-Leffler J., Ernfors P. Science, 2017, 356: 1168-1171.
Oct. 24th 2017 - Stephanie Puig (Gutstein lab)
Site-specific regulation of P2X7 receptor function in microglia gates morphine analgesic tolerance
Leduc-Pessah H., Weilinger N.L., Fan C.Y., Burma N.E., Thompson R.J., Trang T. J Neurosci, 2017, Advanced online publication.
Oct. 31st 2017 - Joe Salsovic (Koerber lab)
Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source
Weir G.A., Middleton S.J., Clark A.J., Daniel, T., Khovanov N., McMahon S.B., Bennett D.L. Brain, 2017: 140, 2570-2585.
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Nov. 7th 2017 - Kristen Smith Edwards (Davis lab)
Ex vivo study of human visceral nociceptors
McGuire C., Boundouki G., Hockley J.R.F., Reed D., Cibert-Goton V., Peiris M., Kung V., Broad J., Aziz Q., Chan C., Ahmed S., Thaha M.A., Sanger G.J., Blackshaw L.A., Knowles C.H., Bulmer D.C. Gut, 2016; 0:1-11
Nov. 14th 2017 - SFN week
Nov. 21st 2017 - Thanksgiving break
Nov. 28th 2017 - Emanuel Loeza (Gold lab)
α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors
Castro J., Harrington A.M., Garcia-Caraballo S., Maddem J., Grundy L., Zhang J., Page G., Miller P.E., Craik D.J., Adams D.J., Brierley S.M. Gut, 2017;66:1083-1094.
Dec. 5th 2017 - Jillian Weeks (Sved lab)
Nicotinic modulation of descending pain control circuitry
Umana I.C., Daniele C.A., Miller B.A., Abburi C., Gallagher K., Brown M.A., Mason P., McGehee D.S. Pain, 2017; 158:1938-1950.
Dec. 12th 2017 - Junichi Hachisuka (Ross lab)
A central neural circuit for itch sensation
Mu D., Deng J., Ke-Fei L., Wu Z-Y., Shi Y-F., Guo W-M., Mao Q-Q., Liu X-J., Li H., Sun Y-G. Science, 2017; 357:695-699.
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Previous Journal Club Schedule Spring 2017
Jan. 3rd 2017 - John Horn
Espinosa-Medina I, Saha O, Boismoreau F, Chettouh Z, Rossi F, Richardson WD and Brunet JF. Science, 2016. 354(6314): p. 893 - 7.
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consensus: developmental biologists and physiologists come head-to-head!
discussion from this journal club led to an eLetter response in Science.
Jan. 10th 2017 - Cedric Peirs (Seal lab)
Arcourt A, Gorham L, Dhandapani R, Prato V, Taberner FJ, Wende H, Gangadharan V, Birchmeier C, Heppenstall PA and Lechner SG. Neuron, 2016. in press
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consensus: very cool paper and outstanding presentation. double kudos!
Jan. 17th 2017 - Qing Liu
Bikoff J, Gabito MI, Rivard AF, Drobac E, Machado TA, Miri A, Brenner-Morton S, Famojure E, Diaz C, Alvarez FJ, Mentis GZ, and Jessel TM. Cell, 2016. 165(1) 207-219
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consensus: so many subtypes!
Jan. 24th 2017 - Keith Vogt
Brasher AK, Becker S, Hoeppli ME, Schweinhardt P. J Neurosci, 2016. 38(18):5013-5020
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consensus: this is an important question
Jan. 31st 2017 - Stephanie Puig (Gutstein Lab)
Corder G, Tawfik VL, Sypek EI, Low SA, Dickinson JR,Sotoudeh C, Clark JD, Barres, BA, Bohlen CJ, and Scherrer G. Nat Medicine, 2017.published online Jan. 16.
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consensus: so interesting -- lots of discussion!
Feb. 7th 2017 - Emanuel Loeza (Gold lab)
Nam Y, Kim J-H, Kim J-H, Jha MK, Jung JY, Lee M-G, Choi I-S, Jang I-S, Lim DG, Hwang S-H, Cho H-J, Suk K. Cell Reports, 2016. 17, 3049-3061
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consensus: nice job Emanuel!
Feb. 14th 2017 - Tara Deemyad (Urban lab)**
Han Q, Kin YH, Wang X, Liu D, Zhang Z-J, Bey AL, Lay M, Chang W, Berta T, Zhang Y, Jiang Y-H, Ji RR. Neuron, 2016. 92, 1279-1293
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consensus: novel presynaptic function for Shank!
Feb. 21st 2017 - Lindsey Snyder (Ross lab)
Francois A, Low SA, Sypek EI, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Ritola KD, Shariff-Naeini R, Deiseroth K, Delp SL,Malenka RC, Juo,L, Hantman AW, and Scherrer G. Neuron, 2017. 93, 1-18
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consensus: Tour de force highlighting cool viral experiments
Feb. 28th 2017 - Jane Hartung (Gold lab)
Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Mousseau M, Shankar JV, Stemkowski PL, Baimoukhametova D, Bains JS, Antle MC, Zamponi GW, Cahill CM, Borgland SL, De Koninck Y, Trang T. Nat Medicine, 2017. Jan 30 [Epub ahead of print]
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consensus: Intriguing results sparked a heated debate over the presence of opioid receptors in glial cells.
March 7th 2017 - Spring Break
March 14th 2017 - Michael Chiang (Ross lab)**
Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Neuron, 2017. 93, 840-853.
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consensus: this was the most hilarious journal club ever.
March 21st 2017 - Sarah Najjar (Albers lab)
Ibrahim MM, Patwardhan A, Galbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Pain, 2017. 158 (2), 347-360.
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consensus: wow! this is very intriguing, and a huge caution for all of us doing real time place aversion with light.
March 28th 2017 - Jami Soloman (Davis lab)
Sinha S, Fu Y, Grimont A, Ketcham, M, Lafaro K, Saglimbeni JA, Askan G, Bailey JM, Melchior JP, Zhong Y, Joo MG, Grbovic-Huezo O, Yang IH, Basturn O, Baker L, Park Y, Kurtz RC, Tuveston D, Leach SD and Pasricha PJ. Cancer Research 2017. in press.
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consensus: cool insight into the mystery of neural-epithelial crosstalk in cancer — substance P!
April 4th 2017 - Colleen Cassidy (Koerber lab)
Wetzel C, Pilfer S, Picci C, Gok C, Hoffman D,Bali KK, Lampe A,Lapatsina L, Fleischer R, St John Smith E, Begay V, Moroni M, Estebanez L, Kuhnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Tuner R, Poulet JFA, Schmoranger J, Poole K and Lewin G. Nature Neuroscience 2017. 20(2), 209-218.
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April 11th 2017 - Junichi Hachisuka (Ross lab)
Yu YQ, Barry DM, Hao Y, Liu XT, Chen ZF. Science 2017. 355, 1072-1076.
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consensus: the optogenetic data are pretty compelling -- who would of guessed that the SCN is involved in itch?
April 18th 2017 - Distinguished Speaker Lunch
April 25th 2017 - Cynthia Arokiaraj (Seal lab)
Du X,Hao H,Yang Y, Huang, S, Wang C, Gigot S, Ramli R, Li X, Jaworski E, Edwards I, Deuchars J, Yanagawa Y, QI J, Guan B, Jaffe DB, Zhang H, Gamper N. J Clin Invest 2017. April 4. [Epub ahead of print].
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Previous Journal Club Fall 2016
Aug. 30th 2017 - Maggie Wright (Koerber lab)
Osteen, J.D., V. Herzig, J. Gilchrist, J.J. Emrick, C. Zhang, X. Wang, J. Castro, S. Garcia-Caraballo, L. Grundy, G.Y. Rychkov, A.D. Weyer, Z. Dekan, E.A.B. Undheim, P. Alewood, C.L. Stucky, S.M. Brierley, A.I. Basbaum, F. Bosmans, G.F. King, and D. Julius. Nature, 2016. 534(7608): p. 494-499.
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consensus: watch out for those spiders - fantastic presentation Maggie of a very interesting paper!
Sept. 6th 2016 - Jami Saloman (Davis lab)
Xie, W., S. Chen, J. A. Strong, A. L. Li, I. P. Lewkowich and J. M. Zhang The Journal of neuroscience 2016.36(33): 8712-8725.
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consensus: microsympa-wow! tricky surgery. very impressive!
Sept. 13th 2016 - Michael Chiang (Ross lab)
Ran C, Hoon MA, Chen X Nat Neurosci. 2016 Sep; 19(9):1201-9.
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consensus: such an exciting proof of concept -- this is the future of understanding spinal microcircuits
Sept. 20th 2016 - Matt Rannals (Urban lab)**
Maza C, Lepousez, G, Nissant A, Valley MT and Lledo PM, Nat Neurosci. 2016 Aug; 36(32):8289-8304.
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consensus: nice job Matt, teasing apart the function of a particular synapse in top-down control!
Sept. 27th 2016 - Sarah Najjar (Albers lab)
Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F, Bergles D, Hanani M, Guan Y, Spray DC, Dong X. Neuron, 2016. 91(5): p. 1085-96.
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consensus: excitatory communication between neurons generated excited communication among scientists.
Sarah, your journal club generated an outstanding discussion!
Oct. 4th 2016 - Cedric Peirs (Seal lab)
Cui L, Miao X, Liang L, Abdus-Saboor I, Olson W, Flemming MS, Ma M, Tao Y, Luo W. Neuron, 2016. 91(5): p. 1137-53.
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consensus: these are some really powerful inhibitory interneurons!
Oct. 11th 2016 - Jorge Pineda (Gold lab)
Tan CH and Mcnaughton PA. Nature, 2016. 460(536).
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consensus: we are feeling warm all over -- cool new heat transducer
Oct. 18th 2016 - Stephanie Puig (Gutstein lab)
Brackley, AD, Gomez, R, Akopian AN, Henry MA and Jeske NA. Cell Report, 2016. 16(2686).
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consensus: location, location, location!
Oct. 25th 2016 - Colleen Cassidy (Koerber lab)
Chang W, Kanda H, Ikeda, R, Ling J, De Berry, JJ, Gu JG PNAS, 2016. 113(37) E5491.
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consensus: I like the feel of this!
Nov. 1st 2016 - Lindsey Snyder (Ross lab) **
Wiltschko AB, Johnson MG, Iurilli G, Peterson ER, Katon JS, Pashkovski SL, Abraira VE, Adams RP and Datta SR Neuron, 2015. 88(1121).
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consensus: Great Journal Club! Can't wait to see improvements enabling the
behaviors
Nov. 8th 2016 - Melissa Giraldo Duque (Gold lab)
Smith ML, Hostetler CM, Heinricher MM, Ryabinin AE Science Advances, 2016. 2(10):e1600855.
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consensus: sensitive creatures!
Nov. 15th 2016 - SfN week
Nov. 22nd 2016 - Thanksgiving week
Nov. 29th 2016 - Marissa Kuzirian (Ross lab)
Sakurai K, Zhao S, Takatoh J, Rodriguez E, Lu J, Leavitt AD, Fu M, Han BX and Wang F Neuron, 2016. 92(1).
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consensus: this paper was outstanding! What an awesome new tool!
Dec. 6th 2016 - Junichi Hachisuka (Ross lab)
Christensen AJ, Iyer SM, Francois A, Vyas S, Ramakrishnan C, Vesuna S, Deisseroth K, Scherrer G and Delp SL Cell Reports, 2016. 17(6)1699.
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consensus: we're lighting up with excitement over this one!
Dec. 13th 2016 - Jane Hartung (Gold lab)
Emery EC, Liuz, AP, Sikander S, Magnusdottir R, Dong X, Wood JN Science Advances, 2016. 2:e1600990.
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consensus: surprisingly controversial. Wow!
discussion from this journal club led to a heated debate